9c24: Difference between revisions
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==Fab F946 in complex with OspCB== | |||
<StructureSection load='9c24' size='340' side='right'caption='[[9c24]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9c24]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi_B31 Borreliella burgdorferi B31] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9C24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9C24 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9c24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9c24 OCA], [https://pdbe.org/9c24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9c24 RCSB], [https://www.ebi.ac.uk/pdbsum/9c24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9c24 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/OSPC2_BORBG OSPC2_BORBG] Major immunodominant protein in mammalian hosts. Required for initial stages of mammalian infection. Inhibits macrophage-mediated phagocytosis of the bacteria. Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue. Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo.[UniProtKB:Q07337] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Borreliella burgdorferi B31]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mantis N]] | |||
[[Category: Rudolph MJ]] | |||
