9ggg: Difference between revisions
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==Cryo-EM structure of Thromboxane A2 receptor-miniGq Protein Complex bound to I-BOP== | |||
<StructureSection load='9ggg' size='340' side='right'caption='[[9ggg]], [[Resolution|resolution]] 3.25Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ggg]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GGG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.25Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IK0:(~{Z})-7-[(1~{S},2~{R},3~{R},4~{R})-3-[(~{E},3~{R})-4-(4-iodanylphenoxy)-3-oxidanyl-but-1-enyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic+acid'>A1IK0</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ggg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ggg OCA], [https://pdbe.org/9ggg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ggg RCSB], [https://www.ebi.ac.uk/pdbsum/9ggg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ggg ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/TA2R_HUMAN TA2R_HUMAN] Bleeding diathesis due to thromboxane synthesis deficiency. Disease susceptibility is associated with variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TA2R_HUMAN TA2R_HUMAN] Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C.<ref>PMID:8613548</ref> Activates adenylyl cyclase.<ref>PMID:8613548</ref> Inhibits adenylyl cyclase.<ref>PMID:8613548</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Caffrey M]] | |||
[[Category: Krawinski P]] | |||
[[Category: Matzov D]] | |||
[[Category: Shalev Benami M]] | |||
Latest revision as of 07:11, 27 August 2025
Cryo-EM structure of Thromboxane A2 receptor-miniGq Protein Complex bound to I-BOP
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