9yd8: Difference between revisions
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==Crystal structure of Phospholipase D (PLD) from Arcanobacterium haemolyticum== | |||
<StructureSection load='9yd8' size='340' side='right'caption='[[9yd8]], [[Resolution|resolution]] 2.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9yd8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinomycetaceae Actinomycetaceae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YD8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9yd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9yd8 OCA], [https://pdbe.org/9yd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9yd8 RCSB], [https://www.ebi.ac.uk/pdbsum/9yd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9yd8 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/PLD_ARCHD PLD_ARCHD] Virulence factor affecting bacterial dissemination and survival within the host. Has magnesium-dependent catalytic activity toward sphingomyelin (SM) and acyl- and alkyl-lysophosphatidylcholine (LPC), but not toward sphingosylphosphorylcholine (SPC) and phosphatidylcholine (PC). Lysophosphatidic acid (LPA), assumed to result from LPC hydrolysis, evokes pathophysiological responses after LPA receptor internalization. Shows hemolytic activity.[UniProtKB:P20626] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Actinomycetaceae]] | |||
[[Category: Large Structures]] | |||
[[Category: Arni RK]] | |||
[[Category: Doherty DZ]] | |||
[[Category: Gismene C]] | |||
[[Category: Nascimento AFZ]] | |||
Latest revision as of 07:21, 15 October 2025
Crystal structure of Phospholipase D (PLD) from Arcanobacterium haemolyticum
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