17S U2 snRNP: Difference between revisions
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==Architectural Blueprint == | ==Architectural Blueprint == | ||
The 17S U2 snRNP exhibits a bipartite structure linked by three molecular bridges, composed of a rigid core and flexible components: | The 17S U2 snRNP exhibits a bipartite structure linked by three molecular bridges, composed of a rigid core and flexible components: | ||
'''5′ Domain (The Rigid Core)''' dominated by the SF3b complex (SF3B1, SF3B3, PHF5A, SF3B5). The overall SF3b core structure remains rigid and functional upon 17S U2 assembly. SF3B1, a key protein, adopts an open conformation in this complex, making the binding site accessible to splicing modulators (e.g., pladienolide B). | * '''5′ Domain (The Rigid Core)''' dominated by the SF3b complex (SF3B1, SF3B3, PHF5A, SF3B5). The overall SF3b core structure remains rigid and functional upon 17S U2 assembly. SF3B1, a key protein, adopts an open conformation in this complex, making the binding site accessible to splicing modulators (e.g., pladienolide B). | ||
* '''3′ Domain (The Flexible Part)''' which contains the Sm core and stem–loops III–IV of the U2 snRNA, bound by the proteins U2-A′ and U2-B″ and is connected to the 5’ domain by three molecular bridges. | |||
== Sequestration of the Branch Site== | == Sequestration of the Branch Site== | ||
