9i5s: Difference between revisions
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The | ==Solution structure of an intramolecular anti-parallel G-quadruplex with a 5'-end overhang.== | ||
<StructureSection load='9i5s' size='340' side='right'caption='[[9i5s]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9i5s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9I5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9I5S FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGM:8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>BGM</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9i5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9i5s OCA], [https://pdbe.org/9i5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9i5s RCSB], [https://www.ebi.ac.uk/pdbsum/9i5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9i5s ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
G-quadruplex structures formed by human telomeric sequences are highly sensitive to subtle sequence variations and local environment. While most structural studies have focused on sequences containing four uninterrupted G-tracts, the structural consequences of splitting a G-tract remain unexplored. Here, we present the NMR solution structure of a human telomeric sequence with the first G-tract split. The structure adopts an antiparallel topology with a disordered GTT segment at the 5'-end. This conformation is preferentially formed at a biologically relevant double-strand/single-strand DNA junction. These findings broaden our understanding of the structural diversity of human telomeric G-quadruplexes. | |||
An antiparallel G-quadruplex structure with a 5'-end overhang forms predominantly at the human telomeric ds-ss DNA junction.,Avendano Avila C, Heddi B Chem Commun (Camb). 2025 Nov 7;61(90):17661-17664. doi: 10.1039/d5cc03633j. PMID:41099088<ref>PMID:41099088</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 9i5s" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Avendano Avila C]] | |||
[[Category: Heddi B]] | |||
Latest revision as of 08:04, 11 December 2025
Solution structure of an intramolecular anti-parallel G-quadruplex with a 5'-end overhang.
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