9uyc: Difference between revisions
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==TxtE mutant-H176FA248F With trp== | |||
<StructureSection load='9uyc' size='340' side='right'caption='[[9uyc]], [[Resolution|resolution]] 1.53Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9uyc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_scabiei_87.22 Streptomyces scabiei 87.22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UYC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9uyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9uyc OCA], [https://pdbe.org/9uyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9uyc RCSB], [https://www.ebi.ac.uk/pdbsum/9uyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9uyc ProSAT]</span></td></tr> | ||
[[Category: Yang | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/TXTE_STRSW TXTE_STRSW] Cytochrome P450 involved in the biosynthesis of thaxtomins, a family of phytotoxins (PubMed:22941045). Catalyzes direct regiospecific 4-nitration of L-tryptophan, the first committed step in thaxtomin A biosynthesis, using NO and O(2) as cosubstrates (PubMed:22941045, PubMed:25182183). It can use spinach ferredoxin (Fd) and spinach ferredoxin reductase (Fr) as artificial electron donors (PubMed:22941045, PubMed:25182183). Cannot use D-tryptophan (PubMed:22941045). In vitro, it can nitrate unnatural substrates that are structurally similar to L-tryptophan with decorated indole side chains and modified amino acid moieties (PubMed:25182183).<ref>PMID:22941045</ref> <ref>PMID:25182183</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Streptomyces scabiei 87 22]] | |||
[[Category: Yang X]] | |||
[[Category: Zhang LJ]] | |||
