9nau: Difference between revisions
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The | ==CryoEM structure of capsid from human astrovirus 1 in complex with human neonatal Fc receptor== | ||
<StructureSection load='9nau' size='340' side='right'caption='[[9nau]], [[Resolution|resolution]] 2.77Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9nau]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_astrovirus_1 Human astrovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NAU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.77Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nau OCA], [https://pdbe.org/9nau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nau RCSB], [https://www.ebi.ac.uk/pdbsum/9nau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nau ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CAPSD_HASV1 CAPSD_HASV1] The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the immature VP70 virion.[UniProtKB:Q9IFX1] The immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry (By similarity). During maturation, VP70 undergoes a loss of 60 peripentonal spikes, which likely plays an important role in viral infectivity (By similarity).[UniProtKB:Q9IFX1] Self-assembles to form an icosahedral capsid with a T=3 symmetry, about 43 nm in diameter (PubMed:26656707). This forms contains only 30 spikes located on the icosahedral 2-fold axes (PubMed:26656707).<ref>PMID:26656707</ref> VP25 and VP27 Forms the spikes at the surface of the virion (PubMed:26656707). This forms contains only 30 spikes located on the icosahedral 2-fold axes (PubMed:26656707). Plays a role in the attachment to target host cell (Probable). This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity).[UniProtKB:Q9IFX1]<ref>PMID:26656707</ref> VP25 and VP27 Forms the spikes at the surface of the virion (PubMed:26656707). This forms contains only 30 spikes located on the icosahedral 2-fold axes (PubMed:26656707). Plays a role in the attachment to target host cell (PubMed:33396308). This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity).[UniProtKB:Q9IFX1]<ref>PMID:26656707</ref> <ref>PMID:33396308</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human astrovirus 1]] | |||
[[Category: Large Structures]] | |||
[[Category: Fremont DH]] | |||
[[Category: Hall PD]] | |||
[[Category: Nelson CA]] | |||
Latest revision as of 07:11, 18 February 2026
CryoEM structure of capsid from human astrovirus 1 in complex with human neonatal Fc receptor
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