8swa: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8swa is ~~ON HOLD until Paper Publication~~

==Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with SAM and PPNP==

~~Authors~~: ~~Bruemmer~~, K.J., ~~Pham~~, V.N., ~~Toh~~, J.D.W.

== Structural highlights ==

<table><tr><td colspan='2'>[[8swa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SWA OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8SWA FirstGlance].

~~Description~~: ~~Crystal structure~~ of ~~the human~~ S-adenosylmethionine ~~synthetase 1 in complex with SAM~~ and ~~PPNP~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.999Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PPK:(DIPHOSPHONO)AMINOPHOSPHONIC+ACID'>PPK</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>

[[Category: ~~Toh, J.D.W~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8swa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8swa OCA], [https://pdbe.org/8swa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8swa RCSB], [https://www.ebi.ac.uk/pdbsum/8swa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8swa ProSAT]</td></tr>

[[Category: Pham~~, V.N~~]]

</table>

[[Category: ~~Bruemmer, K.J~~]]

== Disease ==

[https://www.uniprot.org/uniprot/METK1_HUMAN METK1_HUMAN] Defects in MAT1A are the cause of methionine adenosyltransferase deficiency (MATD) [MIM:[https://omim.org/entry/250850 250850]; also called MAT I/III deficiency. MATD is an inborn error of metabolism resulting in isolated hypermethioninemia. Most patients have no clinical abnormalities, although some neurologic symptoms may be present in rare cases with severe loss of methionine adenosyltransferase activity.<ref>PMID:7560086</ref> <ref>PMID:8770875</ref> <ref>PMID:9042912</ref> <ref>PMID:10677294</ref>

== Function ==

[https://www.uniprot.org/uniprot/METK1_HUMAN METK1_HUMAN] Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Bruemmer KJ]]

[[Category: Pham VN]]

[[Category: Toh JDW]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8swa is ON HOLD  until Paper Publication
+==Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with SAM and PPNP==
+<StructureSection load='8swa' size='340' side='right'caption='[[8swa]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-Authors: Bruemmer, K.J., Pham, V.N., Toh, J.D.W.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8swa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SWA FirstGlance]. <br>
-Description: Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with SAM and PPNP
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.999&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PPK:(DIPHOSPHONO)AMINOPHOSPHONIC+ACID'>PPK</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
-[[Category: Toh, J.D.W]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8swa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8swa OCA], [https://pdbe.org/8swa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8swa RCSB], [https://www.ebi.ac.uk/pdbsum/8swa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8swa ProSAT]</span></td></tr>
-[[Category: Pham, V.N]]
+</table>
-[[Category: Bruemmer, K.J]]
+== Disease ==
+[https://www.uniprot.org/uniprot/METK1_HUMAN METK1_HUMAN] Defects in MAT1A are the cause of methionine adenosyltransferase deficiency (MATD) [MIM:[https://omim.org/entry/250850 250850]; also called MAT I/III deficiency. MATD is an inborn error of metabolism resulting in isolated hypermethioninemia. Most patients have no clinical abnormalities, although some neurologic symptoms may be present in rare cases with severe loss of methionine adenosyltransferase activity.<ref>PMID:7560086</ref> <ref>PMID:8770875</ref> <ref>PMID:9042912</ref> <ref>PMID:10677294</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/METK1_HUMAN METK1_HUMAN] Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Bruemmer KJ]]
+[[Category: Pham VN]]
+[[Category: Toh JDW]]