9mbo: Difference between revisions

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'''Unreleased structure'''


The entry 9mbo is ON HOLD  until Paper Publication
==Focused refinement of RPN1 and the C-terminal helix of midnolin in the substrate-engaged human 26S proteasome==
 
<StructureSection load='9mbo' size='340' side='right'caption='[[9mbo]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9mbo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MBO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MBO FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.83&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mbo OCA], [https://pdbe.org/9mbo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mbo RCSB], [https://www.ebi.ac.uk/pdbsum/9mbo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mbo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MIDN_HUMAN MIDN_HUMAN] Facilitates the ubiquitin-independent proteasomal degradation of stimulus-induced transcription factors such as FOSB, EGR1, NR4A1, and IRF4 to the proteasome for degradation (PubMed:37616343). Promotes also the degradation of other substrates such as CBX4 (By similarity). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.[UniProtKB:D4AE48][UniProtKB:Q3TPJ7]<ref>PMID:37616343</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Liang L]]
[[Category: Qin L]]
[[Category: Zhu C]]
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