Aminopeptidase 3D structures: Difference between revisions
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
*Cysteine aminopeptidase | *Cysteine aminopeptidase | ||
**[[3pw3]] – PdCys-AP – ''Parabacteroides distasonis''<br /> | **[[3pw3]] – PdCys-AP – ''Parabacteroides distasonis''<br /> | ||
*Glutamyl aminopeptidase or aminopeptidase A | *Glutamyl aminopeptidase or aminopeptidase A | ||
**[[4kx7]] – hGlu-AP + Zn – human<br /> | **[[4kx7]] – hGlu-AP + Zn – human<br /> | ||
**[[4kx8]], [[4kxb]] – hGlu-AP + Zn + statin derivative<br /> | **[[4kx8]], [[4kxb]] – hGlu-AP + Zn + statin derivative<br /> | ||
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**[[2wyr]] – PhGlu-AP+Co – ''Pyrococcus horikoshii''<br /> | **[[2wyr]] – PhGlu-AP+Co – ''Pyrococcus horikoshii''<br /> | ||
**[[3kl9]] – SpGlu-AP – ''Streptococcus pneumonia''<br /> | **[[3kl9]] – SpGlu-AP – ''Streptococcus pneumonia''<br /> | ||
*Alanine aminopeptidase or aminopeptidase N or a-aminoacylpeptide hydrolase | *Alanine aminopeptidase or aminopeptidase N or a-aminoacylpeptide hydrolase | ||
**[[8jkt]] – APN ectodomain 1-967 – cat<br /> | **[[8jkt]] – APN ectodomain 1-967 – cat<br /> | ||
**[[2hpo]], [[2dq6]], [[3puu]], [[6g8b]] – EcAPN - ''Escherichia coli''<br /> | **[[2hpo]], [[2dq6]], [[3puu]], [[6g8b]] – EcAPN - ''Escherichia coli''<br /> | ||
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**[[3ebg]] – PfAla-APN - ''Plasmodium falciparum''<br /> | **[[3ebg]] – PfAla-APN - ''Plasmodium falciparum''<br /> | ||
**[[6oiu]] – APN – ''Toxoplasma gondii''<br /> | **[[6oiu]] – APN – ''Toxoplasma gondii''<br /> | ||
*Alanine aminopeptidase binary complex | *Alanine aminopeptidase binary complex | ||
**[[4fyq]], [[5lhd]] - hAla-APN + Zn<br /> | **[[4fyq]], [[5lhd]] - hAla-APN + Zn<br /> | ||
**[[6u7e]], [[6u7f]], [[6u7g]], [[7vpp]], [[7vpq]] – hAPN + spike glycoprotein<br /> | **[[6u7e]], [[6u7f]], [[6u7g]], [[7vpp]], [[7vpq]] – hAPN + spike glycoprotein<br /> | ||
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**[[5zie]] – LpAPN + Asp<br /> | **[[5zie]] – LpAPN + Asp<br /> | ||
**[[7v9n]], [[7v9o]], [[7v9p]], [[7v9q]] – APN + Zn – ''Saccharopolyspora erythrea''<br /> | **[[7v9n]], [[7v9o]], [[7v9p]], [[7v9q]] – APN + Zn – ''Saccharopolyspora erythrea''<br /> | ||
*Alanine aminopeptidase ternary complex | *Alanine aminopeptidase ternary complex | ||
**[[4fyr]] - hAla-APN + Zn + bestatin<br /> | **[[4fyr]] - hAla-APN + Zn + bestatin<br /> | ||
**[[4fys]] - hAla-APN + Zn + angiotensin<br /> | **[[4fys]] - hAla-APN + Zn + angiotensin<br /> | ||
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**[[8t6h]] – PfAPN + Zn + Mg<br /> | **[[8t6h]] – PfAPN + Zn + Mg<br /> | ||
**[[8t7p]] – PfAPN (mutant) + Zn + Mg<br /> | **[[8t7p]] – PfAPN (mutant) + Zn + Mg<br /> | ||
*Aminopeptidase B | *Aminopeptidase B | ||
**[[6cxd]] – YpAPB – ''Yersinia pestis''<br /> | **[[6cxd]] – YpAPB – ''Yersinia pestis''<br /> | ||
**[[6oad]], [[6ov8]] – EcAPB + Zn <br /> | **[[6oad]], [[6ov8]] – EcAPB + Zn <br /> | ||
*Aminopeptidase C see [[Dipeptidyl aminopeptidase]] | *Aminopeptidase C see [[Dipeptidyl aminopeptidase]] | ||
*Aminopeptidase M61 | *Aminopeptidase M61 | ||
**[[7xyo]] – AP + Zn – ''Myxococcus fulvus''<br /> | **[[7xyo]] – AP + Zn – ''Myxococcus fulvus''<br /> | ||
*Proline aminopeptidase or X-Pro aminopeptidase or aminopeptidase P or X-prolyl aminopeptidase or Xaa-Pro dipeptidase | *Proline aminopeptidase or X-Pro aminopeptidase or aminopeptidase P or X-prolyl aminopeptidase or Xaa-Pro dipeptidase | ||
**[[3ctz]] – X hPro-AP<br /> | **[[3ctz]] – X hPro-AP<br /> | ||
**[[1wlr]] - Xaa EcPro-AP<br /> | **[[1wlr]] - Xaa EcPro-AP<br /> | ||
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**[[3azo]] – SmoPro-AP – ''Streptomyces morookaensis''<br /> | **[[3azo]] – SmoPro-AP – ''Streptomyces morookaensis''<br /> | ||
**[[3azp]] - SmoPro-AP (mutant) <br /> | **[[3azp]] - SmoPro-AP (mutant) <br /> | ||
*Proline aminopeptidase binary complex | *Proline aminopeptidase binary complex | ||
**[[2v3x]], [[2v3y]], [[2v3z]] - Xaa EcPro-AP (mutant)+tripeptide<br /> | **[[2v3x]], [[2v3y]], [[2v3z]] - Xaa EcPro-AP (mutant)+tripeptide<br /> | ||
**[[5cnx]] - Xaa EcPro-AP (mutant) + Zn<br /> | **[[5cnx]] - Xaa EcPro-AP (mutant) + Zn<br /> | ||
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**[[3azq]] - SmoPro-AP (mutant) + PGG<br /> | **[[3azq]] - SmoPro-AP (mutant) + PGG<br /> | ||
**[[7e5c]] - Pro-AP (mutant) + Mn – ''Pseudoalteromonas lipolytica''<br /> | **[[7e5c]] - Pro-AP (mutant) + Mn – ''Pseudoalteromonas lipolytica''<br /> | ||
*Proline aminopeptidase higher complex | *Proline aminopeptidase higher complex | ||
**[[1w7v]], [[2bh3]] - Xaa EcPro-AP+Zn+Mg+polypeptide<br /> | **[[1w7v]], [[2bh3]] - Xaa EcPro-AP+Zn+Mg+polypeptide<br /> | ||
**[[2bn7]] - Xaa EcPro-AP+Zn+Mg+Mn+polypeptide<br /> | **[[2bn7]] - Xaa EcPro-AP+Zn+Mg+Mn+polypeptide<br /> | ||
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**[[4s2t]] – CePro-AP 1 + Zn + apstatin <br /> | **[[4s2t]] – CePro-AP 1 + Zn + apstatin <br /> | ||
**[[5wze]] – PaAPP + Ala + Pro – ''Pseudomonas aeruginosa''<br /> | **[[5wze]] – PaAPP + Ala + Pro – ''Pseudomonas aeruginosa''<br /> | ||
*Leucine aminopeptidase | *Leucine aminopeptidase | ||
**[[3qnf]] – hLeu-AP 1<br /> | **[[3qnf]] – hLeu-AP 1<br /> | ||
**[[2yd0]] – hLeu-AP 1 soluble domain<br /> | **[[2yd0]] – hLeu-AP 1 soluble domain<br /> | ||
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**[[5lhj]] – StrLeu-AP 2 – ''Streptomyces''<br /> | **[[5lhj]] – StrLeu-AP 2 – ''Streptomyces''<br /> | ||
**[[5ntg]], [[5ntf]] – Leu-AP – ''Trypanosoma cruzi''<br /> | **[[5ntg]], [[5ntf]] – Leu-AP – ''Trypanosoma cruzi''<br /> | ||
*Leucine aminopeptidase binary complex | *Leucine aminopeptidase binary complex | ||
**[[3mdj]] - hLeu-AP 1 soluble domain + inhibitor<br /> | **[[3mdj]] - hLeu-AP 1 soluble domain + inhibitor<br /> | ||
**[[2ewb]] – bLeu-AP+zofenoprilat <br /> | **[[2ewb]] – bLeu-AP+zofenoprilat <br /> | ||
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**[[7k5k]] – PvLeu-AP M17 + Mn<br /> | **[[7k5k]] – PvLeu-AP M17 + Mn<br /> | ||
**[[7srv]], [[7t3v]] – PfLeu-AP + Zn <br /> | **[[7srv]], [[7t3v]] – PfLeu-AP + Zn <br /> | ||
*Leucine aminopeptidase ternary complex | *Leucine aminopeptidase ternary complex | ||
**[[1bpm]], [[1bpn]] – bLue-AP+Zn+Mg<br /> | **[[1bpm]], [[1bpn]] – bLue-AP+Zn+Mg<br /> | ||
**[[2j9a]] - bLue-AP+Zn + inhibitor<br /> | **[[2j9a]] - bLue-AP+Zn + inhibitor<br /> | ||
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**[[7d1e]] - BtLeu-AP + Zn + acetylhistamine<br /> | **[[7d1e]] - BtLeu-AP + Zn + acetylhistamine<br /> | ||
**[[7y1s]] - BtLeu-AP + Zn + Ni – ''Bacillus amyloliquefaciens''<br /> | **[[7y1s]] - BtLeu-AP + Zn + Ni – ''Bacillus amyloliquefaciens''<br /> | ||
*Leucine-cysteine aminopeptidase or insulin-regulated aminopeptidase | *Leucine-cysteine aminopeptidase or insulin-regulated aminopeptidase | ||
**[[4p8q]], [[5c97]], [[5mj6]], [[8p0i]] – hLeu-Cys-AP + Zn<br /> | **[[4p8q]], [[5c97]], [[5mj6]], [[8p0i]] – hLeu-Cys-AP + Zn<br /> | ||
**[[4pj6]] – hLeu-Cys-AP + Zn + lysine<br /> | **[[4pj6]] – hLeu-Cys-AP + Zn + lysine<br /> | ||
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**[[7zyf]] – hLeu-Cys-AP + Zn + inhibitor<br /> | **[[7zyf]] – hLeu-Cys-AP + Zn + inhibitor<br /> | ||
**[[8cgp]], [[8cgw]] – hLeu-Cys-AP + Zn + malate<br /> | **[[8cgp]], [[8cgw]] – hLeu-Cys-AP + Zn + malate<br /> | ||
*Lysine aminopeptidase | *Lysine aminopeptidase | ||
**[[4x8i]] – PfLys-AP + Zn<br /> | **[[4x8i]] – PfLys-AP + Zn<br /> | ||
*Methionine aminopeptidase | *Methionine aminopeptidase | ||
**[[2gtx]], [[2gu7]] – EcMet-AP<br /> | **[[2gtx]], [[2gu7]] – EcMet-AP<br /> | ||
**[[6iz7]] – EcMet-AP (mutant) – Cryo EM<br /> | **[[6iz7]] – EcMet-AP (mutant) – Cryo EM<br /> | ||
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**[[6k26]] – VcMet-AP – ''Vibrio cholerae''<br /> | **[[6k26]] – VcMet-AP – ''Vibrio cholerae''<br /> | ||
**[[6lvh]] – PyfMet-AP – ''Pyrococcus furiosus''<br /> | **[[6lvh]] – PyfMet-AP – ''Pyrococcus furiosus''<br /> | ||
*Methionine aminopeptidase binary complex | *Methionine aminopeptidase binary complex | ||
**[[3mr1]], [[3mx6]] – Met-AP+Mn – ''Rickettsia prowazekii''<br /> | **[[3mr1]], [[3mx6]] – Met-AP+Mn – ''Rickettsia prowazekii''<br /> | ||
**[[2dfi]], [[1xgm]], [[1xgn]], [[1xgo]], [[1xgs]], [[6m00]] – PyfMet-AP+Co <br /> | **[[2dfi]], [[1xgm]], [[1xgn]], [[1xgo]], [[1xgs]], [[6m00]] – PyfMet-AP+Co <br /> | ||
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**[[6ksg]], [[6lh7]] – VcMet-AP + Ni<br /> | **[[6ksg]], [[6lh7]] – VcMet-AP + Ni<br /> | ||
**[[8onx]] – TtMet-AP + Mn – ''Thermochaetoides thermophila'' <br /> | **[[8onx]] – TtMet-AP + Mn – ''Thermochaetoides thermophila'' <br /> | ||
*Methionine aminopeptidase ternary complex | *Methionine aminopeptidase ternary complex | ||
**[[8bqd]], [[8bqx]] - yMet-AP 1 in ribosome – Cryo EM<br /> | **[[8bqd]], [[8bqx]] - yMet-AP 1 in ribosome – Cryo EM<br /> | ||
**[[3iu7]] – MtMet-AP+Mn +A02<br /> | **[[3iu7]] – MtMet-AP+Mn +A02<br /> | ||
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**[[3mat]] - EcMet-AP (mutant)+Co+bestatin derivative<br /> | **[[3mat]] - EcMet-AP (mutant)+Co+bestatin derivative<br /> | ||
**[[8onz]], [[8oo0]] - TtMet-AP 2 in ribosome – Cryo EM<br /> | **[[8onz]], [[8oo0]] - TtMet-AP 2 in ribosome – Cryo EM<br /> | ||
*Human methionine aminopeptidase | *Human methionine aminopeptidase | ||
**[[8p2k]], [[9f1c]], [[9f1d]], [[9fpz]], [[9fq0]] - hMet-AP 1 in ribosome – Cryo EM<br /> | **[[8p2k]], [[9f1c]], [[9f1d]], [[9fpz]], [[9fq0]] - hMet-AP 1 in ribosome – Cryo EM<br /> | ||
**[[8khm]] - hMet-AP 1 <br /> | **[[8khm]] - hMet-AP 1 <br /> | ||
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**[[5lyw]], [[5lyx]] - hMet-AP 2 (mutant) + Zn + inhibitor<br /> | **[[5lyw]], [[5lyx]] - hMet-AP 2 (mutant) + Zn + inhibitor<br /> | ||
**[[1r58]], [[1r5g]], [[1r5h]], [[5ji6]], [[5jhu]], [[5jfr]], [[5cls]], [[4z7m]], [[5jhu]], [[5jfr]], [[2ea2]], [[2ea4]], [[2ga2]], [[5lyw]] - hMet-AP 2 +Mn+inhibitor<br /> | **[[1r58]], [[1r5g]], [[1r5h]], [[5ji6]], [[5jhu]], [[5jfr]], [[5cls]], [[4z7m]], [[5jhu]], [[5jfr]], [[2ea2]], [[2ea4]], [[2ga2]], [[5lyw]] - hMet-AP 2 +Mn+inhibitor<br /> | ||
*Arginine aminopeptidase | *Arginine aminopeptidase | ||
**[[5cu5]] – hArg-AP 2<br /> | **[[5cu5]] – hArg-AP 2<br /> | ||
**[[4jbs]] – hArg-AP 2 + Zn + inhibitor<br /> | **[[4jbs]] – hArg-AP 2 + Zn + inhibitor<br /> | ||
**[[5ab2]], [[5ab0]] – hArg-AP 2 + Zn + peptide<br /> | **[[5ab2]], [[5ab0]] – hArg-AP 2 + Zn + peptide<br /> | ||
**[[6hc6]], [[6hc7]] – Arg-AP + Zn – ''Bacillus subtilis''<br /> | **[[6hc6]], [[6hc7]] – Arg-AP + Zn – ''Bacillus subtilis''<br /> | ||
*Aspartic acid aminopeptidase | *Aspartic acid aminopeptidase | ||
**[[4dyo]] – hAsp-AP+aspartic hydroxamate<br /> | **[[4dyo]] – hAsp-AP+aspartic hydroxamate<br /> | ||
**[[3var]], [[3vat]] – bAsp-AP<br /> | **[[3var]], [[3vat]] – bAsp-AP<br /> | ||
**[[7u5h]] – bAsp-AP + Zn – Cryo EM<br /> | **[[7u5h]] – bAsp-AP + Zn – Cryo EM<br /> | ||
**[[4eme]], [[6pev]] – PfAsp-AP + Zn<br /> | **[[4eme]], [[6pev]] – PfAsp-AP + Zn<br /> | ||
*Asparagine aminopeptidase | *Asparagine aminopeptidase | ||
**[[3c17]], [[2zak]] – EcAsn-AP (mutant) <br /> | **[[3c17]], [[2zak]] – EcAsn-AP (mutant) <br /> | ||
**[[2zal]] – EcAsn-AP+Asp<br /> | **[[2zal]] – EcAsn-AP+Asp<br /> | ||
**[[2gez]] – Asn-AP – ''Lupinus luteus''<br /> | **[[2gez]] – Asn-AP – ''Lupinus luteus''<br /> | ||
*Serine aminopeptidase | *Serine aminopeptidase | ||
**[[1b65]] – OaSer-AP – ''Ochrobactrum anthropi''<br /> | **[[1b65]] – OaSer-AP – ''Ochrobactrum anthropi''<br /> | ||
*Cytosolic aminopeptidase | *Cytosolic aminopeptidase | ||
**[[3pei]] – FtCyt-AP <br /> | **[[3pei]] – FtCyt-AP <br /> | ||
**[[3ij3]] – Cyt-AP – ''Coxiella burnetii''<br /> | **[[3ij3]] – Cyt-AP – ''Coxiella burnetii''<br /> | ||
*Endoplasmic reticulum aminopeptidase or ERAP1 or ERAP2 | *Endoplasmic reticulum aminopeptidase or ERAP1 or ERAP2 | ||
**[[3qnf]] – hARTS-1<br /> | **[[3qnf]] – hARTS-1<br /> | ||
**[[3rjo]], [[5j5e]] – hARTS-1 ERAP1 domain 530-941<br /> | **[[3rjo]], [[5j5e]] – hARTS-1 ERAP1 domain 530-941<br /> | ||
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**[[4jbs]], [[5k1v]], [[5j6s]], [[6ea4]], [[7nsk]], [[7nup]], [[7p7p]], [[7pfs]], [[7sh0]], [[7z28]] – hARTS-2 + Zn + inhibitor<br /> | **[[4jbs]], [[5k1v]], [[5j6s]], [[6ea4]], [[7nsk]], [[7nup]], [[7p7p]], [[7pfs]], [[7sh0]], [[7z28]] – hARTS-2 + Zn + inhibitor<br /> | ||
**[[5ab0]], [[5ab2]] – hARTS-2 + Zn + peptide<br /> | **[[5ab0]], [[5ab2]] – hARTS-2 + Zn + peptide<br /> | ||
*Puromycin-sensitive aminopeptidase | *Puromycin-sensitive aminopeptidase | ||
**[[8sw0]] – hAP + Zn<br /> | **[[8sw0]] – hAP + Zn<br /> | ||
**[[8sw1]] – hAP + peptide + Zn<br /> | **[[8sw1]] – hAP + peptide + Zn<br /> | ||
*Non-specific aminopeptidase | *Non-specific aminopeptidase | ||
**[[2ek8]] – AnAP – ''Aneurinibacillus''<br /> | **[[2ek8]] – AnAP – ''Aneurinibacillus''<br /> | ||
**[[2ek9]] – AnAP+bestatin<br /> | **[[2ek9]] – AnAP+bestatin<br /> | ||
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**[[4p6y]], [[6nw5]] – TmAP <br /> | **[[4p6y]], [[6nw5]] – TmAP <br /> | ||
**[[6ica]] – LpAP + Zn<br /> | **[[6ica]] – LpAP + Zn<br /> | ||
*Cold-activated aminopeptidase | *Cold-activated aminopeptidase | ||
**[[3cia]] – Col-AP – ''Colwellia psychrerythraea''<br /> | **[[3cia]] – Col-AP – ''Colwellia psychrerythraea''<br /> | ||
*Deblocking aminopeptidase | *Deblocking aminopeptidase | ||
**[[2gre]] – DAP – ''Bacillus cereus''<br /> | **[[2gre]] – DAP – ''Bacillus cereus''<br /> | ||
*Heat stable aminopeptidase | *Heat stable aminopeptidase | ||
**[[2ayi]] – AmpT – ''Thermus thermophilus''<br /> | **[[2ayi]] – AmpT – ''Thermus thermophilus''<br /> | ||
*Aminopeptidase from ''Staphylococcus aureus'' | *Aminopeptidase from ''Staphylococcus aureus'' | ||
**[[1zjc]] - SaAmpS<br /> | **[[1zjc]] - SaAmpS<br /> | ||
**[[1qxw]], [[1qxy]], [[1qxz]] – SaMet-AP+Co+inhibitor <br /> | **[[1qxw]], [[1qxy]], [[1qxz]] – SaMet-AP+Co+inhibitor <br /> | ||
**[[3kzw]] – SaCyt-AP<br /> | **[[3kzw]] – SaCyt-AP<br /> | ||
*''Stereomyces griesus'' aminopeptidase | *''Stereomyces griesus'' aminopeptidase | ||
**[[1xjo]], [[1cp7]] - SGAP <br /> | **[[1xjo]], [[1cp7]] - SGAP <br /> | ||
**[[1qq9]], [[1f2o]], [[1f2p]], [[1tf8]], [[1tf9]], [[1tkf]], [[1tkh]], [[1tkj]], [[1xbu]]] - SGAP + amino acid <br /> | **[[1qq9]], [[1f2o]], [[1f2p]], [[1tf8]], [[1tf9]], [[1tkf]], [[1tkh]], [[1tkj]], [[1xbu]]] - SGAP + amino acid <br /> | ||
*Metalloaminopeptidase | *Metalloaminopeptidase | ||
**[[3q43]], [[3q44]] – PfPFAP (mutant) + bestatin derivative<br /> | **[[3q43]], [[3q44]] – PfPFAP (mutant) + bestatin derivative<br /> | ||
*β-peptidyl AP | *β-peptidyl AP | ||
**[[3n2w]] – SxBapA – ''Sphingosinicella xenopeptidilytica''<br /> | **[[3n2w]] – SxBapA – ''Sphingosinicella xenopeptidilytica''<br /> | ||
**[[3n5i]] – SxBapA (mutant) <br /> | **[[3n5i]] – SxBapA (mutant) <br /> | ||
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**[[3ndv]], [[3nfb]] – SxBapA + ampicillin<br /> | **[[3ndv]], [[3nfb]] – SxBapA + ampicillin<br /> | ||
**[[5tzb]] - AP – ''Burkholderia''<br /> | **[[5tzb]] - AP – ''Burkholderia''<br /> | ||
*M1 family AP | *M1 family AP | ||
**[[3t8v]] – PfAP + Zn + Mg<br /> | **[[3t8v]] – PfAP + Zn + Mg<br /> | ||
**[[4j3b]] – PfAP (mutant) + Zn + Mg + Arg<br /> | **[[4j3b]] – PfAP (mutant) + Zn + Mg + Arg<br /> | ||
Latest revision as of 09:41, 29 March 2026
3D Structures of Aminopeptidase
Updated on 29-March-2026
Tripeptidyl aminotransferase see Tripeptidyl peptidase Dipeptidyl aminotransferase see Dipeptidyl peptidase
