9yl3: Difference between revisions
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The entry | ==State 1 MLL4FC bound to a nucleosome premodified with H2BK120ub and H4K16ac== | ||
<StructureSection load='9yl3' size='340' side='right'caption='[[9yl3]], [[Resolution|resolution]] 3.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9yl3]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YL3 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9yl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9yl3 OCA], [https://pdbe.org/9yl3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9yl3 RCSB], [https://www.ebi.ac.uk/pdbsum/9yl3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9yl3 ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/KMT2D_HUMAN KMT2D_HUMAN] Kabuki syndrome. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KMT2D_HUMAN KMT2D_HUMAN] Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.<ref>PMID:16603732</ref> <ref>PMID:17500065</ref> <ref>PMID:17851529</ref> [https://www.uniprot.org/uniprot/A0A6P6IDI8_PUMCO A0A6P6IDI8_PUMCO] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Roeder R]] | |||
[[Category: Sun J]] | |||
Latest revision as of 07:02, 3 June 2026
State 1 MLL4FC bound to a nucleosome premodified with H2BK120ub and H4K16ac
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