9pn1: Difference between revisions

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'''Unreleased structure'''


The entry 9pn1 is ON HOLD  until Paper Publication
==Crystal structure of Q108K:K40L:T51V:T53C:R58W:T29L:Y19W:Q4A mutant of cellular retinol binding protein II complex with 15-cis-retinal==
<StructureSection load='9pn1' size='340' side='right'caption='[[9pn1]], [[Resolution|resolution]] 1.26&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9pn1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9PN1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.26&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9pn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9pn1 OCA], [https://pdbe.org/9pn1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9pn1 RCSB], [https://www.ebi.ac.uk/pdbsum/9pn1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9pn1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RET2_HUMAN RET2_HUMAN] Intracellular transport of retinol.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We describe the photoisomerization of the retinylidene protonated Schiff base in human retinol-binding protein II (hCRBPII) and the role of water molecules in this process. We characterize the photoisomerization of the 15-cis/all-trans retinylidene protonated Schiff base in this system using UV-visible spectroscopy and atomic-resolution X-ray crystallography. We further demonstrate a process where the pK(a) of the protonated Schiff base is substantially altered by light-induced dehydration of the binding pocket, suggesting novel pathways of photoswitching that rely not on isomerization or conformational change of the chromophore but rather on light-induced reorganization of the protein environment.


Authors: Ehyaei, N., Silva, K., Bingham, C., Geiger, J.H., Borhan, B.
Photoisomerization detected in a fully wavelength-tunable rhodopsin mimic system.,Ehyaei N, Bingham C, Silva K, Nossoni Z, Gavgani HN, Nosrati M, Eaves J, Akhdar M, Vasileiou C, Borhan B, Geiger JH Acta Crystallogr D Struct Biol. 2026 Jun 1;82(Pt 6):664-671. doi: , 10.1107/S2059798326003839. Epub 2026 May 27. PMID:42201784<ref>PMID:42201784</ref>


Description: Crystal structure of Q108K:K40L:T51V:T53C:R58W:T29L:Y19W:Q4A mutant of cellular retinol binding protein II complex with 15-cis-retinal
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Ehyaei, N]]
<div class="pdbe-citations 9pn1" style="background-color:#fffaf0;"></div>
[[Category: Borhan, B]]
== References ==
[[Category: Geiger, J.H]]
<references/>
[[Category: Bingham, C]]
__TOC__
[[Category: Silva, K]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bingham C]]
[[Category: Borhan B]]
[[Category: Ehyaei N]]
[[Category: Geiger JH]]
[[Category: Silva K]]
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