9ws4: Difference between revisions

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'''Unreleased structure'''


The entry 9ws4 is ON HOLD  until Paper Publication
==Cyro-EM structure of the ACT-451840-bound PfMDR1==
 
<StructureSection load='9ws4' size='340' side='right'caption='[[9ws4]], [[Resolution|resolution]] 3.43&Aring;' scene=''>
Authors: Zhao, Z., Li, J., Wang, X., Liu, X., Wang, N., Xu, H., Quan, C., Wang, X., Kato, N., Deng, D., Jing, X.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9ws4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WS4 FirstGlance]. <br>
Description: Cyro-EM structure of the ACT-451840-bound PfMDR1
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.43&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EYJ:3-(4-~{tert}-butylphenyl)-~{N}-[(2~{S})-1-[4-[(4-cyanophenyl)methyl]piperazin-1-yl]-1-oxidanylidene-3-phenyl-propan-2-yl]-~{N}-[[4-(4-ethanoylpiperazin-1-yl)phenyl]methyl]prop-2-enamide'>A1EYJ</scene></td></tr>
[[Category: Xu, H]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ws4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ws4 OCA], [https://pdbe.org/9ws4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ws4 RCSB], [https://www.ebi.ac.uk/pdbsum/9ws4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ws4 ProSAT]</span></td></tr>
[[Category: Wang, X]]
</table>
[[Category: Quan, C]]
== Function ==
[[Category: Zhao, Z]]
[https://www.uniprot.org/uniprot/MDR_PLAF7 MDR_PLAF7] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:35507548, PubMed:37527341). Transports lumefantrine, mefloquine, chloroquine, quinine, quinidine, amodiaquine, piperaquine, dihydroartemisinin and quinacrine (PubMed:35507548).<ref>PMID:35507548</ref> <ref>PMID:37527341</ref>
[[Category: Liu, X]]
== References ==
[[Category: Wang, N]]
<references/>
[[Category: Jing, X]]
__TOC__
[[Category: Kato, N]]
</StructureSection>
[[Category: Li, J]]
[[Category: Large Structures]]
[[Category: Deng, D]]
[[Category: Plasmodium falciparum 3D7]]
[[Category: Deng D]]
[[Category: Jing X]]
[[Category: Kato N]]
[[Category: Li J]]
[[Category: Liu X]]
[[Category: Quan C]]
[[Category: Wang N]]
[[Category: Wang X]]
[[Category: Xu H]]
[[Category: Zhao Z]]

Latest revision as of 15:18, 10 June 2026

Cyro-EM structure of the ACT-451840-bound PfMDR1

9ws4, resolution 3.43Å

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