9rql: Difference between revisions
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The entry | ==GT-C O-Mannosyltransferase TMEM260 incubated with Far-P-Man== | ||
<StructureSection load='9rql' size='340' side='right'caption='[[9rql]], [[Resolution|resolution]] 2.65Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9rql]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RQL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.65Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1JKY:[(2~{S},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]+[(2~{E},6~{E})-3,7,11-trimethyldodeca-2,6,10-trienyl]+hydrogen+phosphate'>A1JKY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rql OCA], [https://pdbe.org/9rql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rql RCSB], [https://www.ebi.ac.uk/pdbsum/9rql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rql ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/TM260_HUMAN TM260_HUMAN] Structural heart defects-renal anomalies syndrome. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TM260_HUMAN TM260_HUMAN] O-mannosyl-transferase that transfers mannosyl residues to the hydroxyl group of serine or threonine residues of proteins (PubMed:37186866). Specifically glycosylates the IPT/TIG domain of target proteins, such as MET and MST1R/RON (PubMed:37186866). TMEM260-mediated O-mannosylated residues are composed of single mannose glycans that are not elongated or modified (PubMed:37186866).<ref>PMID:37186866</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Cifuente JO]] | |||
[[Category: Halim A]] | |||
[[Category: Povolo L]] | |||
[[Category: Ubarretxena-Belandia I]] | |||
Latest revision as of 07:24, 8 July 2026
GT-C O-Mannosyltransferase TMEM260 incubated with Far-P-Man
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