9v2s: Difference between revisions
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==Cryo-EM structure of Runella bGSDM pore== | |||
<StructureSection load='9v2s' size='340' side='right'caption='[[9v2s]], [[Resolution|resolution]] 3.25Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9v2s]] is a 92 chain structure with sequence from [https://en.wikipedia.org/wiki/Runella_zeae_DSM_19591 Runella zeae DSM 19591]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9V2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9V2S FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.25Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9v2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9v2s OCA], [https://pdbe.org/9v2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9v2s RCSB], [https://www.ebi.ac.uk/pdbsum/9v2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9v2s ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: Feng | [https://www.uniprot.org/uniprot/GSDM_RUNZN GSDM_RUNZN] Precursor of a pore-forming protein involved in defense against bacteriophages (By similarity). Cleavage of this precursor by its dedicated, neighboring protease (G563DRAFT_02009) releases the active moiety (gasdermin bGSDM, N-terminus) which inserts into membranes, forming pores and triggering cell death (PubMed:35025633). Expression of bGSDM and its protease is highly toxic in E.coli (PubMed:35025633). Cells expressing the gene pair stop dividing and lose membrane integrity (PubMed:35025633). Both proteins are required to kill E.coli (PubMed:35025633).[UniProtKB:A0A0S2DNG5]<ref>PMID:35025633</ref> Pore-forming protein that causes membrane permeabilization via a pyroptosis-like activity (PubMed:35025633). Makes ring-like pores with walls about 50 Angstroms thick and an interior pore diameter of 200-300 Angstroms, when integrated in liposomes (PubMed:35025633, PubMed:38509367).<ref>PMID:35025633</ref> <ref>PMID:38509367</ref> | ||
[[Category: | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Runella zeae DSM 19591]] | |||
[[Category: Feng Y]] | |||
[[Category: Feng YJ]] | |||
[[Category: Gan JH]] | |||
[[Category: Su Z]] | |||
Latest revision as of 07:28, 8 July 2026
Cryo-EM structure of Runella bGSDM pore
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