Proteasome 3D structures: Difference between revisions

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*Proteasome 13S core
*Proteasome 13S core


**[[7lsx]] – y13S core – yeast - Cryo EM<br />
**[[8tm4]], [[8tm5]] – h13S – human - Cryo EM<br />
**[[5dsv]], [h7e55]] – h13S subunit alpha type 3 <br />
**[[9d4u]] – y13S 7 alpha + 3 beta + UMP1 – yeast - Cryo EM<br />
**[[7lsx]], [[9rl3]] – y13S 7 alpha + 3 beta + UMP1 + chaperone 1,2 - Cryo EM<br />
**[[9rla]], [[9rlt]] – y13S 7 alpha + 1 beta + UMP1 + chaperone 1,2 - Cryo EM<br />
**[[9rm0]], [[9rm1]] – y13S 7 alpha + 2 beta + UMP1 + chaperone 1,2 - Cryo EM<br />
**[[9d0t]] – y13S core 7 alpha + 3 beta + Blm10 – Cryo EM<br />
**[[9d4c]] – y13S core 7 alpha+ 1 beta + Blm10 – Cryo EM<br />


*Proteasome Pre-15S core
*Proteasome Pre-15S core


**[[7ls6]] – yP15S core - Cryo EM<br />
**[[7ls6]] – y15S precursor core - Cryo EM<br />
**[[9rlz]] – y15S precursor - Cryo EM<br />


* Proteasome 20S core
* Proteasome 19S regulatory particle


**[[4r3o]], [[5le5]], [[5lex]] – h20S core – human<br />
**[[9pmj]], [[9pro]], [[9prt]], [[12bm]] – h19S + TXNL1 + PSMD5 + ADP – Cryo EM<br />
**[[6rgq]], [[6r70]], [[7pg9]], [[7v5g]], [[7v5m]] – h20S core – Cryo EM<br />
**[[4ady]] - yPRTS subunit RPN2<br />
 
* Proteasome 20S catalytic core
 
**[[4r3o]], [[5le5]], [[5lex]] – h20S core <br />
**[[6r70]], [[6rgq]], [[7pg9]], [[7v5g]], [[7v5m]], [[8qyl]], [[8qyo]], [[8tm6]] – h20S core 7 alpha 7 beta + UMP1 + chaperones 1,2 – Cryo EM<br />
**[[1iru]] – b20S core - bovine<br />
**[[1iru]] – b20S core - bovine<br />
**[[7dr7]], [[8zf5]] – b20S core – Cryo EM<br />
**[[8azk]], [[8fz5]] – b20S core 7 alpha + 7 beta – Cryo EM<br />
**[[3une]] – m20S core – mouse<br />
**[[3une]] – m20S core – mouse<br />
**[[3unh]] – m20S core (immuno)<br />
**[[6tu3]] – r20S core – rat - Cryo EM<br />
**[[6tu3]] – r20S core – rat - Cryo EM<br />
**[[7qve]], [[8amz]] – 20S – spinach - Cryo EM<br />
**[[7qve]], [[8amz]] – 20S – spinach - Cryo EM<br />
**[[3gpt]], [[3gpw]], [[1g0u]], [[5cz4]] – y20S core<br />
**[[1g0u]], [[3gpt]], [[3gpw]], [[5cz4]] – y20S core<br />
**[[7ls5]], [[7tej]] – y20S core – Cryo EM<br />
**[[7ls5]] – y20S core 7 alpha + 7 beta – Cryo EM<br />
**[[1ryp]], [[3wxr]], [[4qux]], [[4quy]], [[4qv0]], [[4qv1]], [[4qv3]], [[4qv4]], [[4qv5]], [[4qv6]], [[4qv7]], [[4qv8]], [[4qv9]], [[4y8r]], [[4y9y]], [[4ya1]], [[4ya4]], [[5bxl]], [[5cgf]], [[5cza]], [[5d0w]], [[5fg7]], [[6hwc]] - y20S core (mutant)<br />
**[[7tej]] – y20S core 6 alpha + 7 beta – Cryo EM<br />
**[[8t0m]] – y20S core (mutant) – Cryo EM<br />
**[[1ryp]], [[3wxr]], [[4qux]], [[4q7y]], [[4qv0]], [[4qv1]], [[4qv3]], [[4qv4]], [[4qv5]], [[4qv6]], [[4qv7]], [[4qv8]], [[4qv9]], [[4y8r]], [[4y9y]], [[4ya1]], [[4ya4]], [[5bxl]], [[5cza]], [[5d0w]], [[5fg7]], [[5fga]], [[6hwc]], [[9qaf]], [[9qc9]] - y20S core (mutant)<br />
**[[3c91]], [[3c92]], [[1pma]], [[3j9i]], [[5vy3]], [[6bdf]], [[5vy4]], [[8f6a]] – Ta20S core - ''Themoplasma acidophilum'' - Cryo EM<br />
**[[8u7u]], [[9qbi]], [[9qcf]], [[9qck]] – y20S core 7 alpha + 7 beta (mutant) – Cryo EM<br />
**[[6utf]], [[6uti]] – Ta20S core subunits α+β – Cryo EM<br />
**[[9d35]] – y20S core 5 alpha + 3 beta + UMP1 – Cryo EM<br />
**[[9d3i]] – y20S core 5 alpha + 4 beta + UMP1 – Cryo EM<br />
**[[9frw]] – y20S/h20S core<br />
**[[1pma]], [[3c91]], [[3c92]], [[3j9i]], [[5vy3]], [[5vy4]], [[6bdf]], [[8f6a]] – Ta20S core - ''Themoplasma acidophilum'' - Cryo EM<br />
**[[6utf]], [[6uti]], [[9buz]] – Ta20S core subunits α+β – Cryo EM<br />
**[[8f66]] – Ta20S core (mutant) – Cryo EM<br />
**[[8f66]] – Ta20S core (mutant) – Cryo EM<br />
**[[3h4p]] – 20S core – ''Methanocaldococcus janaschii''<br />
**[[3h4p]] – 20S core – ''Methanocaldococcus janaschii''<br />
**[[2h6j]], [[1q5r]] – Re20S core (mutant) – ''Rhodococcus erythropolis''<br />
**[[1q5r]], [[2h6j]] – Re20S core (mutant) – ''Rhodococcus erythropolis''<br />
**[[1q5q]] - Re20S core<br />
**[[1q5q]] - Re20S core<br />
**[[1j2q]] – Af20S core - ''Archaeoglobus fulgidus''<br />
**[[1j2q]] – Af20S core - ''Archaeoglobus fulgidus''<br />
**[[6he7]] – Af20S - Cryo EM<br />
**[[6he7]] – Af20S - Cryo EM<br />
**[[6qm8]] – Lt20S core – ''Leishmania tarentolae'' - Cryo EM<br />
**[[6qm8]] – Lt20S core – ''Leishmania tarentolae'' - Cryo EM<br />
**[[6muw]] – Pf20S – ''Plasmodium falciparum'' - Cryo EM<br />
**[[6muw]] – Pf20S 7 alpha + 7 beta – ''Plasmodium falciparum'' - Cryo EM<br />
**[[3mfe]], [[3mi0]], [[2fhg]] – Mt20S core – ''Mycobacterium tuberculosis''<br />
**[[9y0l]] – Pf20S 7 alpha + 6 beta + UMP1 - Cryo EM<br />
**[[3mka]], [[3hfa]] – Mt20S core (mutant)<br />
**[[9y0k]], [[9y1o]] – Pf20S 7 alpha + 6 beta + endopeptidase - Cryo EM,br />
**[[2fhg]], [[3mfe]], [[3mi0]] – Mt20S core – ''Mycobacterium tuberculosis''<br />
**[[9ce6]] – Mt20S core - Cryo EM<br />
**[[9ce7]], [[9cee]], [[9ceg]] – Mt20S core (mutant) - Cryo EM<br />
**[[3hfa]], [[3mka]] – Mt20S core (mutant)<br />
**[[6z46]] – 20S core subunits α+β – ''Sulfolobus acidocaldarius''<br />
**[[6z46]] – 20S core subunits α+β – ''Sulfolobus acidocaldarius''<br />
**[[8adn]] – 20S – ''Vairimorpha necatrix'' - Cryo EM<br />
**[[8adn]] – 20S – ''Vairimorpha necatrix'' - Cryo EM<br />
**[[9f9p]], [[9f9t]] – 20S – ''Trypanosoma cruzi'' - Cryo EM<br />
* Proteasome 20S core mutated pre1-1
**[[8rvq]] – y20S pre1-1 core – Cryo EM<br />
**[[8rvl]], [[8rvo]], [[9rvp]] – y20S precursor pre1-1 core – Cryo EM<br />
**[[9gbk]] – y20S pre1-1 core + activator – Cryo EM<br />
**[[8t0m]] – y20S pre1-1, pre4-1 core – Cryo EM<br />
* Immunoproteasome 20S
**[[6avo]], [[6e5b]], [[7awe]], [[7b12]] – hI20S + inhibitor - Cryo EM<br />
**[[7dr7]] – bI20S - Cryo EM<br />
**[[7dr6]], [[7drw]] – bI20S + activator – Cryo EM<br />
**[[8ysx]], [[8yvg]], [[8yvp]] – I20S + inhibitor – dog - Cryo EM<br />
**[[3unh]] – mI20S <br />
**[[8ypk]] – mI20S + inhibitor - Cryo EM<br />
**[[3unf]] – mI20S + inhibitor <br />
**[[9ey9]] – yI20S + drug - Cryo EM<br />
**[[4r17]], [[4r18]], [[5cgf]], [[5cgg]], [[5cgh]], [[5cgi]], [[5lai]], [[5laj]], [[5m2b]], [[9frw]], [[9fst]], [[9fsu]], [[9fsv]], [[9ft0]], [[9ft1]] – yI20S + inhibitor - Cryo EM<br />
**[[4qby]], [[4qlq]], [[4qls]], [[4qlt]], [[4qlu]], [[4qlv]] - yI20S core+ peptide inhibitor<br />
* Preholoproteasome
**[[8qys]], [[8tm3]], [[8yix]], [[8yiy]] – hPHP-1 – Cryo EM<br />
**[[8yiz]] – hPHP-2 – Cryo EM<br />
**[[8t08]] – yPHP pre1-1, pre4-1 core – Cryo EM<br />
**[[8u6y]] – yPHP (mutant) – Cryo EM<br />


*Proteasome 20S+activator protein  
*Proteasome 20S+activator protein  


**[[7nan]], [[7nao]], [[7nap]], [[7yqc]], [[7yqd]], [[8cxb]] – h20S + PA28 activator – Cryo EM<br />
**[[7nan]], [[7nao]], [[7nap]], [[7yqc]], [[7yqd]], [[8cvr]], [[8cxb]] – h20S + PA28 activator – Cryo EM<br />
**[[6rey]], [[6kwy]], [[6xmj]], [[7naq]], [[8cvs]] – h20S + activator PA200 – Cryo EM<br />
**[[6kwy]], [[6rey]], [[6xmj]], [[7naq]], [[8cvs]] – h20S + activator PA2 – Cryo EM<br />
**[[7qxn]], [[7qxp]], [[7qxu]], [[7qxw]], [[7qxx]], [[7qy7]], [[7qya]], [[7qyb]] – h20S + activator ZFAND5 – Cryo EM<br />
**[[7qxn]], [[7qxp]], [[7qxu]], [[7qxw]], [[7qxx]], [[7qy7]], [[7qya]], [[7qyb]] – h20S + activator ZFAND5 – Cryo EM<br />
**[[7nht]] – h20S + akirin-2 – Cryo EM<br />
**[[7nht]] – h20S + akirin-2 – Cryo EM<br />
**[[7dr6]], [[7drw]] – b20S + activator – Cryo EM<br />
**[[8bzl]] – h20S core+ Blm42 peptide <br />
**[[4v7o]], [[5nif]] – y20S core+ Blm10 <br />
**[[4v7o]], [[5nif]] – y20S core+ Blm10 <br />
**[[1z7q]], [[1fnt]] – y20S core+PA26<br />
**[[1fnt]], [[1z7q]] – y20S core+PA26<br />
**[[3ipm]], [[3jrm]], [[3jse]], [[3jtl]], [[1ya7]], [[1yar]], [[1yau]] - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U <br />
**[[1ya7]], [[1yar]], [[1yau]], [[3ipm]], [[3jrm]], [[3jse]], [[3jtl]] - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U <br />
**[[5lzp]] - Mt20S subunits a+b + BPA - Cryo EM<br />
**[[5lzp]] - Mt20S subunits a+b + BPA - Cryo EM<br />
**[[6bgo]], [[6bgl]] – Mt20S + activator<br />
**[[6bgl]], [[6bgo]] – Mt20S + activator<br />
**[[6mux]], [[6muv]] – Pf20S + activator PA28 - Cryo EM<br />
**[[6muv]], [[6mux]] – Pf20S + activator PA28 - Cryo EM<br />
**[[6hed]], [[6hec]], [[6hea]], [[6he9]], [[6he8]], [[6he5]] – Af20S + PAN – Cryo EM<br />
**[[6he5]], [[6he8]], [[6he9]], [[6hea]], [[6hec]], [[6hed]] – Af20S + PAN – Cryo EM<br />
**[[6utg]], [[6uth]], [[6utj]] – Ta20S core subunits α+β + activator PA26 – Cryo EM<br />
**[[6utg]], [[6uth]], [[6utj]] – Ta20S core subunits α+β + activator PA26 – Cryo EM<br />


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**[[4r67]] – h20S + cancer drug<br />
**[[4r67]] – h20S + cancer drug<br />
**[[5ley]], [[5lf0]], [[5lf1]], [[5lf3]], [[5lf4]], [[5lf7]], [[5lez]], [[5lf6]], [[6avo]], [[6e5b]], [[7awe]], [[7b12]] - h20S + inhibitor<br />  
**[[5ley]], [[5lez]], [[5lf0]], [[5lf1]], [[5lf3]], [[5lf4]], [[5lf6]], [[5lf7]] - h20S + inhibitor<br />
**[[8ud9]], [[9hmn]], [[9rkz]], [[9yuz]] - h20S + inhibitor – Cryo EM<br />
**[[5a0q]] - h20S + substrate analog<br />
**[[5a0q]] - h20S + substrate analog<br />
**[[9qon]], [[9qoo]] – h20S 7 alpha + importin-9 + akirin-2 – Cryo EM<br />
**[[9qvx]] – h20S 7 alpha + 7 beta + peptide – Cryo EM<br />
**[[8fz6]] – b20S core + PI31 inhibitor – Cryo EM<br />
**[[8fz6]] – b20S core + PI31 inhibitor – Cryo EM<br />
**[[3unb]], [[3unf]] – m20S + inhibitor<br />
**[[3unb]] – m20S + inhibitor<br />
**[[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3bdm]], [[2zcy]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]], [[3mg0]], [[3mg4]], [[3mg6]], [[3mg7]], [[3mg8]], [[3oeu]], [[3oev]], [[3okj]], [[3shj]], [[3un4]], [[3un8]], [[3sdi]], [[3sdk]], [[4fzc]], [[4fzg]], [[4gk7]], [[4eu2]], [[4inr]], [[4int]], [[4inu]], [[4jsq]], [[4jsu]], [[4jt0]], [[4qwx]], [[4qzz]], [[4r17]], [[4r18]], [[4rur]], [[5ahj]], [[4y69]], [[4y6v]], [[4y6z]], [[4y70]], [[4y74]], [[4y75]], [[4y77]], [[4y78]], [[4y7w]], [[4y7x]], [[4y7y]], [[4y80]], [[4y81]], [[4y82]], [[4y8g]], [[4y8h]], [[4y8i]], [[4y8j]], [[4y8k]], [[4y8l]], [[4y8m]], [[5dki]], [[5dkj]], [[5l52]], [[5l54]], [[5l55]], [[4y6a]], [[4y84]], [[4y8n]], [[4y8o]], [[4y8p]], [[4y8q]], [[4y8s]], [[4y8t]], [[4y8u]], [[4y9z]], [[4ya0]], [[4ya2]], [[4ya3]], [[4ya5]], [[4ya7]], [[4ya9]], [[5jhr]], [[5jhs]], [[5lai]], [[4r02]], [[2zcy]], [[5bou]], [[5laj]], [[6gop]], [[6hwb]], [[6hwa]], [[6hw9]], [[6hw8]], [[6hw7]], [[6hw6]], [[6hw5]], [[6hw4]], [[6hw3]], [[6hw0]], [[6hvy]], [[6hvx]], [[6hvw]], [[6hvv]], [[6hvu]], [[6hvt]], [[6hvs]], [[6hvr]], [[6hva]], [[6hv7]], [[6hv5]], [[6hv4]], [[6hv3]], [[6huv]], [[6huu]], [[6huq]], [[6huc]], [[6hub]], [[6htr]], [[6htp]], [[6htd]], [[6htc]], [[6htb]], [[6h39]], [[7o2l]] – y20S core+inhibitor<br />
**[[1jd2]], [[1g65]], [[2f16]], [[2fak]], [[2gpl]], [[2zcy]], [[3bdm]], [[3d29]], [[3dy3]], [[3dy4]], [[3e47]], [[3gpj]], [[3hye]], [[3mg0]], [[3mg4]], [[3mg6]], [[3mg7]], [[3mg8]], [[3oeu]], [[3oev]], [[3okj]], [[3sdi]], [[3sdk]], [[3shj]], [[3un4]], [[3un8]], [[4eu2]], [[4fzc]], [[4fzg]], [[4gk7]], [[4inr]], [[4int]], [[4inu]], [[4jsq]], [[4jsu]], [[4jt0]], [[4qwx]], [[4qzz]], [[4r02]], [[4rur]], [[4y69]], [[4y6a]], [[4y6v]], [[4y6z]], [[4y70]], [[4y74]], [[4y75]], [[4y77]], [[4y78]], [[4y7w]], [[4y7x]], [[4y7y]], [[4y80]], [[4y81]], [[4y82]], [[4y84]], [[4y8g]], [[4y8h]], [[4y8i]], [[4y8j]], [[4y8k]], [[4y8l]], [[4y8m]], [[4y8n]], [[4y8o]], [[4y8p]], [[4y8q]], [[4y8s]], [[4y8t]], [[4y8u]], [[4y9z]], [[4ya0]], [[4ya2]], [[4ya3]], [[4ya5]], [[4ya7]], [[4ya9]], [[5ahj]], [[5bou]], [[5dki]], [[5dkj]], [[5jhr]], [[5jhs]], [[5l52]], [[5l54]], [[5l55]], [[6gop]], [[6h39]], [[6htb]], [[6htc]], [[6htd]], [[6htp]], [[6htr]], [[6hub]], [[6huc]], [[6huq]], [[6huu]], [[6huv]], [[6hv3]], [[6hv4]], [[6hv5]], [[6hv7]], [[6hva]], [[6hvr]], [[6hvs]], [[6hvt]], [[6hvu]], [[6hvv]], [[6hvw]], [[6hvx]], [[6hvy]], [[6h39]], [[6hw0]], [[6hw3]], [[6hw4]], [[6hw5]], [[6hw6]], [[6hw7]], [[6hw8]], [[6hw9]], [[6hwa]], [[6hwb]], [[7o2l]], [[8bw1]], [[8ohz]], [[8oi1]], [[8olr]], [[8rhj]], [[8rhk]], [[8rhl]], [[9aw3]], , [[9aw5]], [[9aw6]], [[9ft0]], [[9ft1]] – y20S core+inhibitor<br />
**[[4qxj]], [[4qz0]], [[4qz1]], [[4qz2]], [[4qz3]], [[4qz4]], [[4qz5]], [[4qz6]], [[4qz7]], [[4qzw]], [[4qzx]], [[4r00]], [[4r02]], [[5cgg]], [[5cgh]], [[5cgi]], [[5d0t]], [[5fgh]], [[6hwf]], [[6g8n]], [[6g8m]], [[6g7f]] – y20S (mutant) + inhibitor<br />
**[[4qxj]], [[4qz0]], [[4qz1]], [[4qz2]], [[4qz3]], [[4qz4]], [[4qz5]], [[4qz6]], [[4qz7]], [[4qzw]], [[4qzx]], [[4r00]], [[4r02]], [[5d0t]], [[5fgh]], [[6g8n]], [[6g8m]], [[6g7f]], [[6hwf]], [[9qai]], [[9qbe]], [[9qbo]], [[9qby]], [[9qd2]] – y20S (mutant) + inhibitor<br />
**[[9fst]], [[9fsu]], [[9fsv]] – y20S/h20S core+inhibitor<br />
**[[4hnp]], [[4hrc]], [[4hrd]], [[4lqi]], [[4ltc]], [[4q1s]], [[6zou]], [[6zp6]], [[6zp8]] - y20S core + antibiotics<br />
**[[4hnp]], [[4hrc]], [[4hrd]], [[4lqi]], [[4ltc]], [[4q1s]], [[6zou]], [[6zp6]], [[6zp8]] - y20S core + antibiotics<br />
**[[4nnn]], [[4nnw]], [[4no1]], [[4no6]], [[4no8]], [[4no9]], [[4qby]], [[4qlq]], [[4qls]], [[4qlt]], [[4qlu]], [[4qlv]] - y20S core+ peptide inhibitor<br />
**[[9qb1]], [[9s78]] - y20S core + drug<br />
**[[9qb4]], [[9qbi]], [[9qbw]], [[9qdf]], [[9qds]] - y20S core (mutant) + drug<br />
**[[4nnn]], [[4nnw]], [[4no1]], [[4no6]], [[4no8]], [[4no9]] - y20S core+ peptide inhibitor<br />
**[[5cz6]], [[5cz7]] - y20S (mutant) + peptide inhibitor<br />
**[[5cz6]], [[5cz7]] - y20S (mutant) + peptide inhibitor<br />
**[[7teo]] – y20S core + FUB1 – Cryo EM<br />
**[[7teo]] – y20S core + FUB1 – Cryo EM<br />
**[[3h6f]], [[3h6i]], [[3hf9]], [[2fhh]], [[3krd]], [[6ode]], [[6ocz]], [[6ocw]], [[6wnk]] – Mt20S core+inhibitor<br />
**[[2fhh]], [[3h6f]], [[3h6i]], [[3hf9]], [[3krd]], [[6ocw]], [[6ocz]], [[6ode]], [[6wnk]] – Mt20S core+inhibitor<br />
**[[9ce8]] – Mt20S core + drug – Cryo EM<br />
**[[8d6v]], [[8d6w]], [[8d6x]], [[8d6y]] – Mt20S core+ ATPase + ATP – Cryo EM<br />
**[[8d6v]], [[8d6w]], [[8d6x]], [[8d6y]] – Mt20S core+ ATPase + ATP – Cryo EM<br />
**[[3nzj]], [[3nzw]], [[3nzx]] - y20S + TMC-95A mimic ligand<br />
**[[3nzj]], [[3nzw]], [[3nzx]] - y20S + TMC-95A mimic ligand<br />
**[[4qvl]], [[4qw4]], [[4z1l]], [[3tdd]], [[4j70]] – y20S + cancer drug<br />
**[[3tdd]], [[4j70]], [[4qvl]], [[4qw4]], [[4z1l]] – y20S + cancer drug<br />
**[[4qvm]], [[4qvn]], [[4qvp]], [[4qvq]], [[4qvv]], [[4qvw]], [[4qvy]], [[4qw0]], [[4qw1]], [[4qw3]], [[4qw5]], [[4qw6]], [[4qw7]], [[4qwf]], [[4qwg]], [[4qwi]], [[4qwj]], [[4qwk]], [[4qwl]], [[4qwr]], [[4qws]], [[4qwu]], [[5cz8]], [[5cz9]], [[5fgd]], [[5fge]], [[5fgf]], [[5fgg]], [[5fgi]], [[5fhs]], [[5d0z]], [[5d0x]], [[5d0v]], [[5d0s]], [[5cz5]], [[5bxn]], [[6hwe]], [[6hwd]] - y20S (mutant) + cancer drug<br />
**[[4qvm]], [[4qvn]], [[4qvp]], [[4qvq]], [[4qvv]], [[4qvw]], [[4qvy]], [[4qw0]], [[4qw1]], [[4qw3]], [[4qw5]], [[4qw6]], [[4qw7]], [[4qwf]], [[4qwg]], [[4qwi]], [[4qwj]], [[4qwk]], [[4qwl]], [[4qwr]], [[4qws]], [[4qwu]], [[5bxn]], [[5cz5]], [[5cz8]], [[5cz9]], [[5d0s]], [[5d0v]], [[5d0x]], [[5d0z]], [[5fgd]], [[5fge]], [[5fgf]], [[5fgg]], [[5fgi]], [[5fhs]], [[6hwd]], [[6hwe]] - y20S (mutant) + cancer drug<br />
**[[4x6z]] - y20S + modulator<br />
**[[4x6z]] - y20S + modulator<br />
**[[5gjq]] - y20S + ubiquitin carboxyl hydrolase 14 + polyubiquitin<br />
**[[5gjq]] - y20S + ubiquitin carboxyl hydrolase 14 + polyubiquitin<br />
Line 83: Line 138:
**[[5l5x]], [[5l60]], [[5l61]] - y20S + h20S beta5c + h20S beta6 + inhibitor<br />
**[[5l5x]], [[5l60]], [[5l61]] - y20S + h20S beta5c + h20S beta6 + inhibitor<br />
**[[5l5y]], [[5l5z]] - y20S + h20S beta5c + h20S beta6 + cancer drug<br />
**[[5l5y]], [[5l5z]] - y20S + h20S beta5c + h20S beta6 + cancer drug<br />
**[[5l5d]], [[5l5h]], [[5l5q]], [[5l5i]], [[5l5j]], [[5l5o]], [[5l5p]], [[5l5s]], [[5l5t]], [[5l5u]], [[5l5v]], [[5l62]], [[5l63]], [[5l64]], [[5l68]], [[5l69]], [[5l6a]], [[5l6c]], [[5m2b]] - y20S + h20S beta5i + h20S beta6 + inhibitor<br />
**[[5l5d]], [[5l5h]], [[5l5i]], [[5l5j]], [[5l5o]], [[5l5p]], [[5l5q]], [[5l5s]], [[5l5t]], [[5l5u]], [[5l5v]], [[5l62]], [[5l63]], [[5l64]], [[5l68]], [[5l69]], [[5l6a]], [[5l6c]] - y20S + h20S beta5i + h20S beta6 + inhibitor<br />
**[[5l5e]], [[5l5f]] - y20S + h20S beta5i + h20S beta6 + cancer drug<br />
**[[5l5e]], [[5l5f]] - y20S + h20S beta5i + h20S beta6 + cancer drug<br />
**[[5l65]], [[5l66]] - y20S + m20S beta5i + m20S beta6 + cancer drug<br />
**[[5l65]], [[5l66]] - y20S + m20S beta5i + m20S beta6 + cancer drug<br />
**[[5l67]], [[5l6b]] - y20S + m20S beta5i + m20S beta6 + inhibitor<br />
**[[5l67]], [[5l6b]] - y20S + m20S beta5i + m20S beta6 + inhibitor<br />
**[[5fmg]] - Pf20S + inhibitor - ''Plasmodium falciparum'' - Cryo EM<br />
**[[5tho]], [[5trg]], [[5trr]], [[5trs]], [[5try]], [[5ts0]] - Mt20S + peptide<br />
**[[5trr]], [[5trs]], [[5try]], [[5ts0]], [[5tho]], [[5trg]] - Mt20S + peptide<br />
**[[3h6f]], [[3h6i]], [[3hf9]], [[2fhh]], [[3krd]], [[6ode]], [[6ocz]], [[6ocw]] – Mt20S core+inhibitor<br />
**[[6qm7]] – Lt20S + leishmania drug – Cryo EM<br />
**[[6qm7]] – Lt20S + leishmania drug – Cryo EM<br />
**[[6td5]] – Lt20S + inhibitor – Cryo EM<br />
**[[6td5]] – Lt20S + inhibitor – Cryo EM<br />
**[[7lxt]] – Pf20S + cancer drug – Cryo EM<br />
**[[7lxt]] – Pf20S + cancer drug – Cryo EM<br />
**[[7lxu]], [[7lxv]] – Pf20S + inhibitor – Cryo EM<br />
**[[5fmg]], [[7lxu]], [[7lxv]], [[8g6e]], [[8g6f]], [[8w2f]], [[9o3e]], [[9o3f]], [[9yuy]] – Pf20S + inhibitor – Cryo EM<br />
**[[6tcz]], [[7zyj]], [[8olu]] – 20S + inhibitor - ''Leishmania donovani'' – Cryo EM<br />
**[[6tcz]], [[7zyj]], [[8olu]] – 20S + inhibitor - ''Leishmania donovani'' – Cryo EM<br />
**[[8oix]], [[8p0t]] – 20S + inhibitor - ''Trichomonas vaginalis'' – Cryo EM<br />
**[[8f7k]] – Ta20S core + peptide – Cryo EM<br />
**[[8f7k]] – Ta20S core + peptide – Cryo EM<br />


Line 108: Line 162:
**[[5nyw]] – PRTS β subunit – ''Yersinia bercovieri''<br />
**[[5nyw]] – PRTS β subunit – ''Yersinia bercovieri''<br />


*Proteasome partial 26S particle
*Proteasome 26S particle regulatory non-ATPase subunit 1
 
**[[2n3t]] - yPRTS regulatory non-ATPase subunit 1 – NMR<br />
**[[2n3u]], [[2n3v]], [[2n3w]] - yPRTS regulatory non-ATPase subunit 1 + L20 – NMR<br />
**[[2nbw]] - yPRTS regulatory non-ATPase subunit 1 + Rad23 UBL domain – NMR<br />
 
*Proteasome 26S particle regulatory non-ATPase subunits 1,2
 
**[[8usd]] - hPRTS regulatory non-ATPase subunits 1,2 + Nub1 + regulatory subunits 4,7 – Cryo EM<br />
 
*Proteasome 26S particle regulatory non-ATPase subunits 1,13
 
**[[5v1z]], [[6oi4]] - hPRTS regulatory non-ATPase subunits 1,13 + ubiquitin<br />
**[[6uyi]], [[6uyj]] - hPRTS regulatory non-ATPase subunits 1,13 + ubiquitin – NMR<br />
**[[6co4]] - hPRTS regulatory non-ATPase subunit 1 peptide + regulatory non-ATPase subunit 13 - NMR<br />
 
*Proteasome 26S particle regulatory non-ATPase subunit 2 or Rpn1
 
**[[7uih]] - hPRTS regulatory non-ATPase subunit 2 + antibody – Cryo EM<br />
**[[7ujd]] - hPRTS regulatory non-ATPase subunit 2 + antibody +  peptide – Cryo EM<br />
 
 
*Proteasome 26S particle regulatory non-ATPase subunit 4 ofr Rpn10
 
**[[1p9c]] – hPRTS regulatory non-ATPase subunit 4 C-terminal<br />
**[[1p9d]] - hPRTS regulatory non-ATPase subunit 4 C-terminal + HHR23A ubiquitin-like domain<br />
**[[1uel]] - hPRTS regulatory non-ATPase subunit 4 C-terminal + HHR23A ubiquitin-like domain - NMR<br />
**[[1yx4]] - hPRTS regulatory non-ATPase subunit 4 – NMR<br />
**[[1yx5]], [[1yx6]], [[2kde]], [[2kdf]], [[6mun]] - hPRTS regulatory non-ATPase subunit 4+ubiquitin – NMR<br />
**[[6u19]] - hPRTS regulatory non-ATPase subunit 4 RAZUL domain + ubiquitin protein ligase E3A peptide – NMR<br />
**[[8j4a]], [[8jtk]], [[8jtl]], [[8pfd]] - PRTS regulatory non-ATPase subunit 4 + SAP05 – ''Arabidosis thaliana''<br />
**[[2x5n]] - fyPRTS regulatory non-ATPase subunit 4 VWA domain – fission yeast<br />
**[[5ln1]] - yPRTS regulatory non-ATPase subunit 4 + polyubiquitin<br />
 
*Proteasome 26S particle regulatory non-ATPase subunit 5 or Rpn5
 
**[[5zmr]] - yPRTS regulatory non-ATPase subunit 5 N terminal – NMR<br />
 
*Proteasome 26S particle regulatory non-ATPase subunit 7 or Rpn9
 
**[[2o95]], [[2o96]] - hPRTS regulatory non-ATPase subunit 7<br />
**[[3vlf]] - yPRTS regulatory non-ATPase subunit 7 + DNA mismatch repair protein<br />
**[[2mr3]] - yPRTS regulatory non-ATPase subunit 7 – NMR<br />
**[[2mqw]] - yPRTS regulatory non-ATPase subunit 7 N terminal – NMR<br />
**[[2mri]] - yPRTS regulatory non-ATPase subunit 7 C terminal – NMR<br />
 
*Proteasome 26S particle regulatory non-ATPase subunit 8
 
**[[3kw6]] - hPRTS regulatory non-ATPase subunit 8<br />
**[[2krk]] - hPRTS regulatory non-ATPase subunit 8 – NMR<br />
 
*Proteasome 26S particle regulatory non-ATPase subunits 8,11
 
**[[4o8x]], [[4o8y]], [[4owp]], [[5w83]]  - yPRTS regulatory non-ATPase subunits 8,11 <br />
**[[4ocl]], [[4ocm]], [[4ocn]] - yPRTS regulatory non-ATPase subunits 8,11 + nanobody<br />
**[[5u4p]] - yPRTS regulatory non-ATPase subunits 8,11 + S31<br />
 
*Proteasome 26S particle regulatory non-ATPase subunit 11
 
**[[3txm]], [[3txn]] – PRTS regulatory non-ATPase subunit 11 – ''Drosophila melanogaster''<br />
**[[6fju]], [[6fjv]], [[6fno]] - CcPRTS regulatory non-ATPase subunit 11 homolog – Candidatus caldiarchaeum<br />
**[[6fnn]] - CcPRTS regulatory non-ATPase subunit 11 homolog + ubiquitin<br />
 
*Proteasome 26S particle regulatory non-ATPase subunit 12
 
**[[4b0z]] - fyPRTS regulatory non-ATPase subunit 12<br />
 
*Proteasome 26S particle regulatory non-ATPase subunit 13 or ADRM1
 
**[[4uel]] - hPRTS regulatory non-ATPase subunit 13 DEUBAD domain 266-388 + UCH-L5 + ubiquitin<br />
**[[2z4d]] - yPRTS regulatory non-ATPase subunit 13<br />
**[[2z59]] - mPRTS regulatory non-ATPase subunit 13+ubiquitin <br />
 
*Proteasome 26S particle regulatory non-ATPase subunit 14
 
**[[3vl1]] - yPRTS regulatory non-ATPase subunit 14 (mutant)<br />
 
 
*Proteasome 26S particle Dss1 subunit


**[[7e55]] - hPRTS α type-3 subunit – Cryo EM<br />
**[[6uyi]], [[6uyj]] - hPRTS subunit 1 + ubiquitin + ADRM1 – NMR<br />
**[[5l4k]] - hPRTS lid - Cryo EM<br />
**[[5dsv]] - hPRTS subunit a type-3<br />
**[[1p9c]] – hPRTS subunit 4 C-terminal<br />
**[[1p9d]] - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain<br />
**[[1uel]] - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain - NMR<br />
**[[1yx4]] - hPRTS subunit 4 – NMR<br />
**[[1yx5]], [[1yx6]], [[2kde]], [[2kdf]], [[6mun]] - hPRTS subunit 4+ubiquitin – NMR<br />
**[[6u19]] - hPRTS subunit 4 RAZUL domain + ubiquitin protein ligase E3A peptide – NMR<br />
**[[2o95]], [[2o96]] - hPRTS subunit 7<br />
**[[3kw6]] - hPRTS subunit 8<br />
**[[2krk]] - hPRTS subunit 8 – NMR<br />
**[[1qym]], [[1uoh]] - hPRTS subunit 10<br />
**[[1tr4]] - hPRTS subunit 10 – NMR<br />
**[[4nik]] - hPRTS subunit 10 + scFv<br />
**[[7iuh]] - hPRTS subunit RPN1 + antibody – Cryo EM<br />
**[[7ujd]] - hPRTS subunit RPN1 + antibody + peptide – Cryo EM<br />
**[[6oi4]] - hPRTS subunit RPN13+RPN2+ubiquitin<br />
**[[3t5x]] - hPRTS subunit Dss1 + PCI domain-containing protein 2<br />
**[[3t5x]] - hPRTS subunit Dss1 + PCI domain-containing protein 2<br />
**[[2dvw]], [[2dwz]] - mPRTS subunit 10 + hPRTS subunit 6B – mouse<br />
**[[8yjb]] - hPRTS subunit Dss1 + INTAC complex – Cryo EM<br />
**[[3aji]] - mPRTS subunit 10 +  subunit 4<br />
**[[8yjb]], [[9vd9]] - hPRTS subunit Dss1 + INTAC-PEC complex – Cryo EM<br />
**[[2z59]] - mPRTS subunit RPN13+ubiquitin<br />
**[[5l4k]] - hPRTS subunit Dss1 + Lid complex – Cryo EM<br />
**[[8jtk]], [[8jtl]], [[8pfd]] - PRTS subunit RPN10 + SAP05 – ''Arabidosis thaliana''<br />
 
**[[2x5n]] - PRTS subunit RPN10 VWA domain – fission yeast<br />
*Proteasome 26S particle SEM1 subunit
**[[4ady]] - yPRTS subunit RPN2<br />
 
**[[5zmr]] - yPRTS subunit RPN5 N terminal – NMR<br />
**[[28wy]], [[28xa]], [[28xb]] - hPRTS subunit SEM1 + SAC3D1 + PCID2 – Cryo EM <br />
**[[3vlf]] - yPRTS subunit 7 + DNA mismatch repair protein<br />
**[[8r7j]], [[8r7k]], [[9upc]] - hPRTS subunit SEM1 in TREX-2 complex – Cryo EM<br />
**[[4o8x]], [[4o8y]], [[5w83]], [[4owp]] - yPRTS subunit RPN8 + RPN11<br />
**[[9dlp]], [[9t6n]], [[9opb]] - hPRTS subunit SEM1 + spliceosome RNA helicase + Germinal-center associated nuclear protein + PCI-domain containing protein – Cryo EM<br />
**[[4ocl]], [[4ocm]], [[4ocn]] - yPRTS subunit RPN8 + RPN11 + nanobody<br />
**[[9dlr]], [[9dlv]], [[9t6l]] - hPRTS subunit SEM1 + spliceosome RNA helicase + leukocyte receptor cluster + PCI-domain containing protein – Cryo EM<br />
**[[5u4p]] - yPRTS subunit RPN8 + RPN11 + S31<br />
**[[9rv1]] - hPRTS subunit SEM1 + spliceosome RNA helicase + + PCI-domain containing protein + SAC3 domain containing protein – Cryo EM<br />
**[[2mr3]] - yPRTS subunit RPN9 – NMR<br />
**[[3jck]] - hPRTS subunit SEM1 + Lid complex – Cryo EM<br />
**[[2mqw]] - yPRTS subunit RPN9 N terminal – NMR<br />
**[[3t5v]], [[4trq]], [[5g5p]], [[5l3t]] - yPRTS subunit SEM1 + nuclear mRNA export proteins SAC3 and THP1<br /  
**[[2mri]] - yPRTS subunit RPN9 C terminal – NMR<br />
**[[5ln1]] - yPRTS subunit RPN10 + polyubiquitin<br />
**[[4b0z]] - yPRTS subunit RPN12<br />
**[[2z4d]] - yPRTS subunit RPN13<br />
**[[3vl1]] - yPRTS subunit RPN14 (mutant)<br />
**[[3t5v]], [[5l3t]], [[5g5p]], [[4trq]] - yPRTS subunit SEM1 + nuclear mRNA export proteins SAC3 and THP1<br /  
**[[3txm]], [[3txn]] – PRTS subunit P42B – ''Drosophila melanogaster''<br />
**[[5ubp]] - yPRTS subunit SEM1 + nuclear mRNA export protein THP1 + leucine permease transcriptional regulator<br />
**[[5ubp]] - yPRTS subunit SEM1 + nuclear mRNA export protein THP1 + leucine permease transcriptional regulator<br />
**[[7ewf]], [[7ewm]] - yPRTS subunit SEM1 + CSN12 + THP3<br />
**[[8u8c]] - yPRTS subunit SEM1 + SAC3 + THP1 + SUB2<br />
**[[8u8d]], [[8u8e]] - yPRTS subunit SEM1 + RNA helicase + nuclear mRNA export factor + THP1 – Cryo EM<br />
For  hPRTS regulatory non-ATPase subunit 10  or Gankyrin see [[Ankyrin]]<br />


*Proteasome 26S particle
*Proteasome 26S particle


**[[5l4g]], [[5gjr]], [[5ln3]], [[5t0c]], [[5t0g]], [[5t0h]], [[5t0i]], [[5t0j]], [[5vhs]], [[5vhr]], [[5vhq]], [[5vhp]], [[5vho]], [[5vhn]], [[5vhm]], [[5vhj]], [[5vhi]], [[5vhh]], [[5vhf]], [[5vgz]], [[5vft]], [[5vfr]], [[5vfo]] - h26S - Cryo EM<br />
**[[5gjr]], [[5l4g]], [[5ln3]], [[5t0c]], [[5t0g]], [[5t0h]], [[5t0i]], [[5t0j]], [[5vfo]], [[5vfp]], [[5vfq]], [[5vfr]], [[5vfs]], [[5vft]], [[5vfu]], [[5vgz]], [[5vhf]], [[5vhh]], [[5vhi]], [[5vhj]], [[5vhm]], [[5vhn]], [[5vho]], [[5vhp]], [[5vhq]], [[5vhr]], [[5vhs]], [[8jri]], [[9iwr]] - h26S - Cryo EM<br />
**[[6msb]], [[6msd]], [[6mse]], [[6msg]], [[6msh]], [[6msj]], [[6msk]] – h26S + ADP + ATP - Cryo EM<br />
**[[8cvt]], [[9nkf]] – h26S + ATP - Cryo EM<br />
**[[5m32]] - h26S + inhibitor - Cryo EM<br />
**[[6msb]], [[6msd]], [[6mse]], [[6msg]], [[6msh]], [[6msj]], [[6msk]], [[9u7r]] – h26S + ADP + ATP - Cryo EM<br />
**[[5m32], [[9vue]], [[9vuf]], [[9vug]]] - h26S + inhibitor - Cryo EM<br />
**[[8jrt]], [[8jti]], [[8k0g]], [[9k4j]], [[9k4k]], [[9k4l]], [[9k4m]], [[9k4o]], [[9k4p]], [[9k4r]], [[9k4s]], [[9k4t]], [[9k4u]], [[9k4v]], [[9k4w]], [[9k4x]], [[9k4y]], [[9k4z]], [[9k50]], [[9k51]], [[9k53]], [[9k54]], [[9k55]], [[9k56]], [[9k57]], [[9k58]], [[9k59]], [[9k5a]], [[9k5b]], [[9k5c]], [[9k5d]], [[9k5e]] – h26S + ubiquitin – Cryo EM<br />
**[[6wjd]], [[6wjn]] – h26S + ubiquitin + E3 ubiquitin ligase – Cryo EM<br />
**[[6wjd]], [[6wjn]] – h26S + ubiquitin + E3 ubiquitin ligase – Cryo EM<br />
**[[7w37]], [[7w38]], [[7w39]], [[7w3a]], [[7w3b]], [[7w3c]], [[7w3f]], [[7w3g]], [[7w3h]], [[7w3j]], [[7w3j]], [[7w3k]], [[7w3m]] – h26S + USP14 – Cryo EM<br />
**[[9heu]], [[9szt]], [[9szv]] – h26S + Bag1 + ADP + ATP - Cryo EM<br />
**[[6epf]], [[6epe]], [[6epd]], [[6epc]] – r26S - Cryo EM<br />
**[[7w37]], [[7w38]], [[7w39]], [[7w3a]], [[7w3b]], [[7w3c]], [[7w3f]], [[7w3g]], [[7w3h]], [[7w3i]], [[7w3j]], [[7w3k]], [[7w3m]] – h26S + USP14 – Cryo EM<br />
**[[3j47]], [[4cr2]], [[4cr3]], [[4cr4]], [[5wvi]], [[5mpc]], [[6j2c]], [[6j2n]], [[6j2q]], [[6j2x]], [[6j30]], [[6fvt]], [[6fvu]], [[6fvv]], [[6fvw]], [[6fvx]], [[6fvy]] – y26S – Cryo EM<br />
**[[9bui]], [[9bv1]], [[9bv2]], [[9bv3]], [[9m2w]], [[9mbp]], [[9mbq]], [[9u3l]], [[9u4m]], [[9uf8]], [[9ug9]], [[9wbg]], [[22mm]] – h26S + midnolin – Cryo EM<br />
**[[9w39]] – h26S + midnolin + ubiquitin  – Cryo EM<br />
**[[9nki]], [[9nkg]] – h26S + midnolin + SEM1 + ATP + ADP  – Cryo EM<br />
**[[9nkj]] – h26S + SEM1 + ATP + ADP  – Cryo EM<br />
**[[9e8h]], [[9e8i]], [[9pmo]], [[9pmq]] – h26S + TXNL1 – Cryo EM<br />
**[[8usb]], [[8usc]], [[9e8k]], [[9pdl]], [[9pf1]] – h26S + Nub1/FAT10 + ATP + ADP – Cryo EM<br />
**[[9bw4]], [[9e8g]], [[9e8j]], [[9e8l]], [[9e8n]], [[9e8o]] – h26S + Nub1/FAT10 + TXNL1 + ATP + ADP – Cryo EM<br />
**[[8zzq]] – h26S + Ecm29 – Integrative<br />
**[[6epc], [[6epd]], [[6epe]], [[6epf]] – r26S - Cryo EM<br />
**[[3j47]], [[3jco]], [[3jcp]], [[4cr2]], [[4cr3]], [[4cr4]], [[5mpc]], [[5wvi]], [[6fvt]], [[6fvu]], [[6fvv]], [[6fvw]], [[6fvx]], [[6fvy]] [[6j2c]], [[6j2n]], [[6j2q]], [[6j2x]], [[6j30]] – y26S – Cryo EM<br />
**[[5wvk]] - y26S + ADP - Cryo EM<br />
**[[5wvk]] - y26S + ADP - Cryo EM<br />
**[[5mp9]], [[5mpa]], [[5mpd]], [[5mpe]] - y26S + ATP - Cryo EM<br />
**[[5mp9]], [[5mpa]], [[5mpd]], [[5mpe]] - y26S + ATP - Cryo EM<br />
**[[9cgc]] - y26S + ATP+ ADP - Cryo EM<br />
**[[5mpb]] - y26S + AMPPNP - Cryo EM<br />
**[[5mpb]] - y26S + AMPPNP - Cryo EM<br />
**[[4g4s]] – y26S + proteasome assembly chaperon 1 & 2<br />
**[[4g4s]] – y26S + proteasome assembly chaperon 1 & 2<br />
**[[5a5b]] - y26S + UBP6 - Cryo EM<br />
**[[5a5b]] - y26S + UBP6 - Cryo EM<br />
**[[6ef3]], [[6ef2]], [[6ef1]], [[6ef0]] – y26S + ubiquitin-L40 – Cryo EM<br />
**[[6ef0]], [[6ef1]], [[6ef2]], [[6ef3]] – y26S + ubiquitin-L40 – Cryo EM<br />
**[[7qo3]] – y26S + Ubp6 – Cryo EM<br />
**[[7qo3]] – y26S + Ubp6 – Cryo EM<br />
**[[7qo4]] – y26S + Ubp6 + UbVS – Cryo EM<br />
**[[7qo4]] – y26S + Ubp6 + UbVS – Cryo EM<br />
**[[7qo5]], [[7qo6]] – y26S + Rpt1 + Rk + Ubp6 + UbVS – Cryo EM<br />
**[[7qo5]], [[7qo6]] – y26S + Rpt1 + Rk + Ubp6 + UbVS – Cryo EM<br />
**[[8t08]] – y26S + UMP1 + proteasome chaperone +  proteasome assembly chaperone – Cryo EM<br />
}}
}}


[[Category:Topic Page]]
[[Category:Topic Page]]
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