9zhh: Difference between revisions
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==Cryo-EM structure of IGFBP7 dodecamer. The 3D refinement was focused on the central part of the dodecamer, which contains 12 IgC2 domains.== | |||
<StructureSection load='9zhh' size='340' side='right'caption='[[9zhh]], [[Resolution|resolution]] 3.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9zhh]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZHH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZHH FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zhh OCA], [https://pdbe.org/9zhh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zhh RCSB], [https://www.ebi.ac.uk/pdbsum/9zhh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zhh ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Cai | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/IBP7_HUMAN IBP7_HUMAN] Familial retinal arterial macroaneurysm. The disease is caused by variants affecting the gene represented in this entry. | ||
== Function == | |||
[https://www.uniprot.org/uniprot/IBP7_HUMAN IBP7_HUMAN] Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.<ref>PMID:8117260</ref> <ref>PMID:8939990</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bai XC]] | |||
[[Category: Cai K]] | |||
[[Category: Zhang XW]] | |||
Latest revision as of 20:36, 29 July 2026
Cryo-EM structure of IGFBP7 dodecamer. The 3D refinement was focused on the central part of the dodecamer, which contains 12 IgC2 domains.
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