21gl: Difference between revisions
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==Structure of the GPI-AP transporter in state2== | |||
<StructureSection load='21gl' size='340' side='right'caption='[[21gl]], [[Resolution|resolution]] 3.25Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[21gl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=21GL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=21GL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.25Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=21gl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=21gl OCA], [https://pdbe.org/21gl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=21gl RCSB], [https://www.ebi.ac.uk/pdbsum/21gl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=21gl ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TMED9_HUMAN TMED9_HUMAN] Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB.<ref>PMID:10852829</ref> <ref>PMID:14600267</ref> <ref>PMID:16595549</ref> <ref>PMID:18287528</ref> <ref>PMID:19296914</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Hua ZK]] | |||
[[Category: Yu HJ]] | |||
[[Category: Zhang D]] | |||
[[Category: Zhang M]] | |||
Latest revision as of 04:48, 13 August 2026
Structure of the GPI-AP transporter in state2
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