22tr: Difference between revisions
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==Cryo-EM structure of Crimean-Congo hemorrhagic fever virus RNA polymerase in complex with 5' vRNA promotor== | |||
<StructureSection load='22tr' size='340' side='right'caption='[[22tr]], [[Resolution|resolution]] 2.75Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[22tr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Crimean-Congo_hemorrhagic_fever_virus_strain_IbAr10200 Crimean-Congo hemorrhagic fever virus strain IbAr10200]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=22TR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=22TR FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.75Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=22tr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=22tr OCA], [https://pdbe.org/22tr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=22tr RCSB], [https://www.ebi.ac.uk/pdbsum/22tr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=22tr ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/L_CCHFI L_CCHFI] Displays RNA-directed RNA polymerase, deubiquitinating and deISGylase activities. RNA-dependent RNA polymerase is responsible for replication and transcription of the viral RNA genome. The deubiquitinating activity cleaves both ubiquitinated and ISGylated products and may therefore regulate ubiquitin and ISG15 dependent innate immunity. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Crimean-Congo hemorrhagic fever virus strain IbAr10200]] | |||
[[Category: Large Structures]] | |||
[[Category: Liang Z]] | |||
[[Category: Ma J]] | |||
[[Category: Wu H]] | |||
[[Category: Yang K]] | |||
Latest revision as of 04:55, 19 August 2026
Cryo-EM structure of Crimean-Congo hemorrhagic fever virus RNA polymerase in complex with 5' vRNA promotor
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