9igs: Difference between revisions

Latest revision as of 16:47, 8 September 2026

Mouse teneurin-3 A1B1 isoform; microphthalmia-associated R2579W mutant; compact dimer conformation

Structural highlights

9igs is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3Å
Ligands:	NAG
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TEN3_MOUSE Involved in neural development by regulating the establishment of proper connectivity within the nervous system (PubMed:17478416, PubMed:17803360, PubMed:22499796, PubMed:23028443, PubMed:25406022, PubMed:29414938). Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion (PubMed:29414938). Promotes homophilic adhesion in a splicing isoform-dependent manner: most isoforms (isoform-type A and type-B) can mediate homophilic interaction (PubMed:29414938). Promotes axon guidance (PubMed:23028443). Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway (PubMed:17803360, PubMed:22499796, PubMed:23028443, PubMed:25406022). Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC) (PubMed:17803360, PubMed:23028443). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes (PubMed:20636325).^[1] ^[2] ^[3] ^[4] ^[5] ^[6] ^[7]

References

↑ Leamey CA, Glendining KA, Kreiman G, Kang ND, Wang KH, Fassler R, Sawatari A, Tonegawa S, Sur M. Differential gene expression between sensory neocortical areas: potential roles for Ten_m3 and Bcl6 in patterning visual and somatosensory pathways. Cereb Cortex. 2008 Jan;18(1):53-66. PMID:17478416 doi:10.1093/cercor/bhm031
↑ Leamey CA, Merlin S, Lattouf P, Sawatari A, Zhou X, Demel N, Glendining KA, Oohashi T, Sur M, Fässler R. Ten_m3 regulates eye-specific patterning in the mammalian visual pathway and is required for binocular vision. PLoS Biol. 2007 Sep;5(9):e241. PMID:17803360 doi:10.1371/journal.pbio.0050241
↑ Murakami T, Fukunaga T, Takeshita N, Hiratsuka K, Abiko Y, Yamashiro T, Takano-Yamamoto T. Expression of Ten-m/Odz3 in the fibrous layer of mandibular condylar cartilage during postnatal growth in mice. J Anat. 2010 Sep;217(3):236-44. PMID:20636325 doi:10.1111/j.1469-7580.2010.01267.x
↑ Merlin S, Horng S, Marotte LR, Sur M, Sawatari A, Leamey CA. Deletion of Ten-m3 induces the formation of eye dominance domains in mouse visual cortex. Cereb Cortex. 2013 Apr;23(4):763-74. PMID:22499796 doi:10.1093/cercor/bhs030
↑ Dharmaratne N, Glendining KA, Young TR, Tran H, Sawatari A, Leamey CA. Ten-m3 is required for the development of topography in the ipsilateral retinocollicular pathway. PLoS One. 2012;7(9):e43083. PMID:23028443 doi:10.1371/journal.pone.0043083
↑ Tran H, Sawatari A, Leamey CA. The glycoprotein Ten-m3 mediates topography and patterning of thalamostriatal projections from the parafascicular nucleus in mice. Eur J Neurosci. 2015 Jan;41(1):55-68. PMID:25406022 doi:10.1111/ejn.12767
↑ Berns DS, DeNardo LA, Pederick DT, Luo L. Teneurin-3 controls topographic circuit assembly in the hippocampus. Nature. 2018 Feb 15;554(7692):328-333. PMID:29414938 doi:10.1038/nature25463

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Leamey CA, Glendining KA, Kreiman G, Kang ND, Wang KH, Fassler R, Sawatari A, Tonegawa S, Sur M. Differential gene expression between sensory neocortical areas: potential roles for Ten_m3 and Bcl6 in patterning visual and somatosensory pathways. Cereb Cortex. 2008 Jan;18(1):53-66. PMID:17478416 doi:10.1093/cercor/bhm031

[2] Leamey CA, Merlin S, Lattouf P, Sawatari A, Zhou X, Demel N, Glendining KA, Oohashi T, Sur M, Fässler R. Ten_m3 regulates eye-specific patterning in the mammalian visual pathway and is required for binocular vision. PLoS Biol. 2007 Sep;5(9):e241. PMID:17803360 doi:10.1371/journal.pbio.0050241

[3] Murakami T, Fukunaga T, Takeshita N, Hiratsuka K, Abiko Y, Yamashiro T, Takano-Yamamoto T. Expression of Ten-m/Odz3 in the fibrous layer of mandibular condylar cartilage during postnatal growth in mice. J Anat. 2010 Sep;217(3):236-44. PMID:20636325 doi:10.1111/j.1469-7580.2010.01267.x

[4] Merlin S, Horng S, Marotte LR, Sur M, Sawatari A, Leamey CA. Deletion of Ten-m3 induces the formation of eye dominance domains in mouse visual cortex. Cereb Cortex. 2013 Apr;23(4):763-74. PMID:22499796 doi:10.1093/cercor/bhs030

[5] Dharmaratne N, Glendining KA, Young TR, Tran H, Sawatari A, Leamey CA. Ten-m3 is required for the development of topography in the ipsilateral retinocollicular pathway. PLoS One. 2012;7(9):e43083. PMID:23028443 doi:10.1371/journal.pone.0043083

[6] Tran H, Sawatari A, Leamey CA. The glycoprotein Ten-m3 mediates topography and patterning of thalamostriatal projections from the parafascicular nucleus in mice. Eur J Neurosci. 2015 Jan;41(1):55-68. PMID:25406022 doi:10.1111/ejn.12767

[7] Berns DS, DeNardo LA, Pederick DT, Luo L. Teneurin-3 controls topographic circuit assembly in the hippocampus. Nature. 2018 Feb 15;554(7692):328-333. PMID:29414938 doi:10.1038/nature25463

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9igs is ON HOLD  until Paper Publication
+==Mouse teneurin-3 A1B1 isoform; microphthalmia-associated R2579W mutant; compact dimer conformation==
+<StructureSection load='9igs' size='340' side='right'caption='[[9igs]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9igs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IGS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IGS FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9igs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9igs OCA], [https://pdbe.org/9igs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9igs RCSB], [https://www.ebi.ac.uk/pdbsum/9igs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9igs ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TEN3_MOUSE TEN3_MOUSE] Involved in neural development by regulating the establishment of proper connectivity within the nervous system (PubMed:17478416, PubMed:17803360, PubMed:22499796, PubMed:23028443, PubMed:25406022, PubMed:29414938). Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion (PubMed:29414938). Promotes homophilic adhesion in a splicing isoform-dependent manner: most isoforms (isoform-type A and type-B) can mediate homophilic interaction (PubMed:29414938). Promotes axon guidance (PubMed:23028443). Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway (PubMed:17803360, PubMed:22499796, PubMed:23028443, PubMed:25406022). Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC) (PubMed:17803360, PubMed:23028443). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes (PubMed:20636325).<ref>PMID:17478416</ref> <ref>PMID:17803360</ref> <ref>PMID:20636325</ref> <ref>PMID:22499796</ref> <ref>PMID:23028443</ref> <ref>PMID:25406022</ref> <ref>PMID:29414938</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Gogou C]]
+[[Category: Meijer DH]]

9igs: Difference between revisions

Latest revision as of 16:47, 8 September 2026

Mouse teneurin-3 A1B1 isoform; microphthalmia-associated R2579W mutant; compact dimer conformation

Structural highlights

Function

References

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