32fd: Difference between revisions
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==Cryo-EM structure of cariprazine-bound D3 dopamine receptor with mini-Go (alternative conformation)== | |||
<StructureSection load='32fd' size='340' side='right'caption='[[32fd]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[32fd]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=32FD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=32FD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7RU:3-[4-[2-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethyl-urea'>7RU</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=32fd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=32fd OCA], [https://pdbe.org/32fd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=32fd RCSB], [https://www.ebi.ac.uk/pdbsum/32fd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=32fd ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN] Hereditary essential tremor. Disease susceptibility is associated with variations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN] Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.<ref>PMID:19520868</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Keseru GM]] | |||
[[Category: Kiss DJ]] | |||
[[Category: Shalev-Benami M]] | |||
[[Category: Yardeni EH]] | |||
Latest revision as of 09:15, 30 September 2026
Cryo-EM structure of cariprazine-bound D3 dopamine receptor with mini-Go (alternative conformation)
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