1f84: Difference between revisions

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[[Image:1f84.~~gif~~|left|200px]]

[[Image:1f84.png|left|200px]]

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~~'''~~SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIID~~'''~~

===SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIID===

~~==Overview==~~

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~~Translation of~~ the ~~hepatitis C virus~~ (~~HCV~~) ~~polyprotein~~ is ~~initiated at an internal ribosome entry site (IRES) element in~~ the ~~5' untranslated region of HCV RNA~~. ~~The HCV IRES element interacts directly with the 40S subunit, and biochemical experiments have implicated RNA elements near the AUG start codon as required for IRES~~-~~40S subunit complex formation. The data we present here show that two RNA stem loops, domains IIId and IIIe, are involved in IRES~~-~~40S subunit interaction. The structures of the two RNA domains were solved by NMR spectroscopy and reveal structural features that may explain their role in IRES function.~~

The line below this paragraph, {{ABSTRACT_PUBMED_11101890}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11101890 is the PubMed ID number.

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==About this Structure==

Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F84 OCA].

Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F84 OCA].

==Reference==

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[[Category: Rna structure]]

[[Category: Sarcin/ricin loop]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 16~~:00:54 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:51:03 2008''

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-[[Image:1f84.gif|left|200px]]
+{{Seed}}
+[[Image:1f84.png|left|200px]]
 <!--
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 {{STRUCTURE_1f84|  PDB=1f84  |  SCENE=  }}
-'''SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIID'''
+===SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIID===
-==Overview==
+<!--
-Translation of the hepatitis C virus (HCV) polyprotein is initiated at an internal ribosome entry site (IRES) element in the 5' untranslated region of HCV RNA. The HCV IRES element interacts directly with the 40S subunit, and biochemical experiments have implicated RNA elements near the AUG start codon as required for IRES-40S subunit complex formation. The data we present here show that two RNA stem loops, domains IIId and IIIe, are involved in IRES-40S subunit interaction. The structures of the two RNA domains were solved by NMR spectroscopy and reveal structural features that may explain their role in IRES function.
+The line below this paragraph, {{ABSTRACT_PUBMED_11101890}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11101890 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11101890}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F84 OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F84 OCA].
 ==Reference==
@@ Line 31: / Line 35: @@
 [[Category: Rna structure]]
 [[Category: Sarcin/ricin loop]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:00:54 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 02:51:03 2008''