1k4r: Difference between revisions

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[[Image:1k4r.~~gif~~|left|200px]]

[[Image:1k4r.png|left|200px]]

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~~'''~~Structure of Dengue Virus~~'''~~

===Structure of Dengue Virus===

~~==Overview==~~

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The first structure of a flavivirus has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of glycoprotein E into the electron density map. The virus core, within a lipid bilayer, ~~has a less-ordered structure than the external~~, ~~icosahedral scaffold of 90 glycoprotein E dimers. The three E monomers per icosahedral asymmetric unit do not have quasiequivalent symmetric environments. Difference maps indicate~~ the ~~location of the small membrane protein M relative~~ to the ~~overlaying scaffold of E dimers~~. ~~The structure suggests that flaviviruses~~, ~~and by analogy also alphaviruses, employ a fusion mechanism in which~~ the ~~distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane~~.

The line below this paragraph, {{ABSTRACT_PUBMED_11893341}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11893341 is the PubMed ID number.

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==About this Structure==

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[[Category: Glycoprotein e from tick-borne encephalitis virus]]

[[Category: Icosahedral virus]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ 2 22:18:20 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:46:24 2008''

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-[[Image:1k4r.gif|left|200px]]
+{{Seed}}
+[[Image:1k4r.png|left|200px]]
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 {{STRUCTURE_1k4r|  PDB=1k4r  |  SCENE=  }}
-'''Structure of Dengue Virus'''
+===Structure of Dengue Virus===
-==Overview==
+<!--
-The first structure of a flavivirus has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of glycoprotein E into the electron density map. The virus core, within a lipid bilayer, has a less-ordered structure than the external, icosahedral scaffold of 90 glycoprotein E dimers. The three E monomers per icosahedral asymmetric unit do not have quasiequivalent symmetric environments. Difference maps indicate the location of the small membrane protein M relative to the overlaying scaffold of E dimers. The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane.
+The line below this paragraph, {{ABSTRACT_PUBMED_11893341}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11893341 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11893341}}
 ==About this Structure==
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 [[Category: Glycoprotein e from tick-borne encephalitis virus]]
 [[Category: Icosahedral virus]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:18:20 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 09:46:24 2008''