2b6b: Difference between revisions

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[[Image:2b6b.gif|left|200px]]
{{Seed}}
[[Image:2b6b.png|left|200px]]


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{{STRUCTURE_2b6b|  PDB=2b6b  |  SCENE=  }}  
{{STRUCTURE_2b6b|  PDB=2b6b  |  SCENE=  }}  


'''Cryo EM structure of Dengue complexed with CRD of DC-SIGN'''
===Cryo EM structure of Dengue complexed with CRD of DC-SIGN===




==Overview==
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Dengue virus (DENV) is a significant human pathogen that causes millions of infections and results in about 24,000 deaths each year. Dendritic cell-specific ICAM3 grabbing nonintegrin (DC-SIGN), abundant in immature dendritic cells, was previously reported as being an ancillary receptor interacting with the surface of DENV. The structure of DENV in complex with the carbohydrate recognition domain (CRD) of DC-SIGN was determined by cryo-electron microscopy at 25 A resolution. One CRD monomer was found to bind to two glycosylation sites at Asn67 of two neighboring glycoproteins in each icosahedral asymmetric unit, leaving the third Asn67 residue vacant. The vacancy at the third Asn67 site is a result of the nonequivalence of the glycoprotein environments, leaving space for the primary receptor binding to domain III of E. The use of carbohydrate moieties for receptor binding sites suggests a mechanism for avoiding immune surveillance.
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(as it appears on PubMed at http://www.pubmed.gov), where 16469696 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16469696}}
 
==Disease==
Known disease associated with this structure: Dengue fever, protection against OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604672 604672]], HIV type 1, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604672 604672]], Mycobacterium tuberculosis, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604672 604672]]


==About this Structure==
==About this Structure==
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[[Category: Cryo em dengue crd dc-sign]]
[[Category: Cryo em dengue crd dc-sign]]
[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:54:42 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:27:17 2008''
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