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CD3 (or Cluster of Differentiation 3) is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM). Drugs which bind to CD3 are tested as immunorepressants.
Human CD3 extracellular domain complex with antibody light chain and heavy chain (PDB entry 1sy6).[1]
- ↑ Kjer-Nielsen L, Dunstone MA, Kostenko L, Ely LK, Beddoe T, Mifsud NA, Purcell AW, Brooks AG, McCluskey J, Rossjohn J. Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7675-80. Epub 2004 May 10. PMID:15136729 doi:10.1073/pnas.0402295101
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3D structures of CD3
Updated on 23-November-2015
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- CD3 ε chain
- 1sy6 – hCD3 ITAM + Syk kinase – human
- 2jxb – hCD3 domain SH3-1
- 2k4f – mCD3 ITAM – mouse - NMR
- 3r08 – mCD3 extracellular domain + antibody
- 2mim – CD3 – chicken
- CD3 εγ dimer
- 1jbj – hCD3 extracellular domain - NMR
- 1sy6 – hCD3 extracellular domain + antibody
- CD3 εδ dimer
- 1xiw – hCD3 extracellular domain + antibody
- 1xmw – mCD3 extracellular domain ε/sCD3 extracellular domain δ – sheep
- CD3 ζ chain
- 1ygr, 2oq1 – hCD3 ITAM + CD45 protein tyrosine phosphatase
- 3ik5, 3ioz – hCD3 ITAM + NEF
- 2hac – hCD3 transmembrane domain - NMR
References
