Phosphoribosyltransferase 3D structures

3D structures of phosphoribosyltransferase

Updated on 08-July-2026

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• Orotate phosphoribosyltransferase
  • 2pry - yOPRT – yeast
    
  • 1oro, 6tai - EcOPRT – Escherichia coli
    
  • 1j7j - StOPRT – Salmonella typhimurium
    
  • 2aee - OPRT – Streptococcus pyogenes
    
  • 3dez - OPRT – Streptococcus mutans
    
  • 2yzk – OPRT – Aeropyrum pernix
    
  • 3m3h - BaOPRT – Bacillus anthracis
    
  • 3mjd - OPRT – Francisella tularensis
    
  • 3n2l - VcOPRT – Vibrio cholera
    
  • 3qw3, 3qw4 - OPRT – Leishmania infantum
    
  • 2p1z – OPRT – Corynebacterium diphtheriae
    
  • 4fym - PfOPRT – Plasmodium falciparum
    
  • 4ohc – BcOPRT – Burkholderia cenocepacia
    
  • 9e5g – BcOPRT – Cryo EM
    
  • 4paw – HpOPRT – Helicobacter pylori
    
• Orotate phosphoribosyltransferase complex
  • 2qcn, 2wns, 3l0k, 3l0n, 3mo7 – hOPRT + UMP derivative
    
  • 3mi2 - hOPRT + pyrazofurin monophosphate
    
  • 4hib, 4hkp - hOPRT + inhibitor
    
  • 2prz - yOPRT + OMP
    
  • 4wml, 4wn3 - yOPRT + PRPP
    
  • 2ps1 - yOPRT + orotate + PRPP
    
  • 1sto – StOPRT + OMP
    
  • 4rv4 - BaOPRT + PRPP
    
  • 1lh0, 1opr - StOPRT + orotate + PRPP
    
  • 5hki – MtOPRT + Fe-citrate – Mycobacterium tuberculosis
    
  • 5hkf - MtOPRT + PRPP
    
  • 5hkl - MtOPRT (mutant) + Pi
    
  • 6taj, 6tak - EcOPRT + orotate
    
• Hypoxanthine PRT
  • 7cmj - LdHPRT – Leishmania donovani
    
• Hypoxanthine-guanine phosphoribosyltransferase or purine/pyrimidine PRT
  • 1z7g - hHPRT
    
  • 1grv, 1nul, 8cag, 9k8m - EcHPRT
    
  • 1dbr - TgHPRT – Toxoplasma gondii
    
  • 1tc1 - TcHPRT – Trypanosoma cruzi
    
  • 5euc - TcHPRT 21-241
    
  • 1r3u - TteHPRT – Thermoanaerobacter tengongensis
    
  • 2geb - TteHPRT (mutant)
    
  • 1vdm - PhHPRT – Pyrococcus horikoshii
    
  • 3h83, 3hvu, 3o7m, 4qyi - BaHPRT
    
  • 3acb - TtHPRT – Thermus thermophilus
    
  • 3ohp - VcHPRT
    
  • 4lyy – HPRT – Shewanella pealeana
    
  • 4pfq – HPRT – Brachybacterium faecium
    
  • 4qri – HPRT – Leptospira interrogans
    
  • 4rqa, 4rqb – HPRT – Staphylococcus aureus
    
  • 5xtk, 6kp5 – YpeHGPRT – Yersinia pestis
    
  • 6kqc - YpeHGPRT (mutant)
    
  • 5esw - LpHGPRT – Legionella pneumophila
    
  • 6igs - FtHGPRT
    
  • 6d9q - BaHGPRT
    
• Hypoxanthine-guanine phosphoribosyltransferase binary complex with nucleotide
  • 1hmp - hHGPRT + GMP - human
    
  • 3gep, 3ggj, 4jis, 4jlt - hHGPRT + guanine derivative
    
  • 2jky, 2jkz, 2xbu - yHGPRT + GMP
    
  • 1a97, 1a98 - EcHGPRT (mutant) + GMP
    
  • 1g9s - EcHGPRT + IMP
    
  • 1g9t - EcHGPRT + GMP
    
  • 5knr, 5kns, 5knt, 5knu, 5knv, 5knx - EcHGPRT + nucleoside phosphonate
    
  • 1hgx - HGPRT + GMP – Tritrichomonas foetus
    
  • 1qk3 - TgHGPRT + GMP
    
  • 1qk4 - TgHGPRT + IMP
    
  • 1p19 - TcHGPRT + IMP
    
  • 1p17 - TcHGPRT (mutant) + IMP
    
  • 1yfz - TteHGPRT + IMP
    
  • 1pzm - LtHGPRT + GMP – Leishmania tarentolae
    
  • 1y0b - BsHGPRT + GTP – Bacillus subtilis
    
  • 2fxv - BsHGPRT + GMP
    
  • 6w1i - BsHGPRT + PPGPP
    
  • 3kb8 - BaHGPRT + GMP
    
  • 6d9s - BaHGPRT + PPGPP
    
  • 3acc - TtHGPRT + GMP
    
  • 3acd - TtHGPRT + IMP
    
  • 1d6n - LdAPRT + AMP derivative
    
  • 4zfn - SsHGPRT + GMP
    
  • 5kam - TbHGPRT + IMP - Trypanosoma brucei
    
  • 5jv5, 6mxc - TbHGPRT + GMP
    
  • 6mxb, 6mxg - TbHGPRT + XMP
    
  • 6mxd - TbHGPRT + IMP
    
  • 5ipf - HGPRT + IMP – Schistosoma mansoni
    
  • 5esx - LpHGPRT + GMP
    
• Hypoxanthine-guanine PRT binary complex
  • 3ggc - hHGPRT + hypoxanthine derivative
    
  • 4ijq, 4rab, 4rac, 4rad, 4ran, 4rao, 4raq, 5hia, 5w8v, 6bnj, 7san, 8tr1 - hHGPRT + inhibitor
    
  • 8tpv, 8tpy - hHGPRT (mutant) + inhibitor
    
  • 5bsk, 5brn - hHGPRT (mutant) + nucleoside phosphonate
    
  • 4kn6 - hHGPRT + antiviral agent
    
  • 1dqp - GiHGPRT + imucillin – Giardia intestinalis
    
  • 3ozf - PfHGPRT + hypoxanthine
    
  • 3ozg - PfHGPRT + inhibitor
    
  • 5kny - MtHGPRT + inhibitor
    
  • 4rht, 4rhu, 4rhx - MtHGPRT + nucleoside phosphonate
    
  • 1dqn - GiHGPRT + transition state analog
    
  • 4z1o - SsHGPRT + PRPP - Sulfolobus solfataricus
    
  • 6bo7 - HGPRT + inhibitor – Plasmodium vivax
    
  • 5jsq, 5k51, 5kap, 6aps, 6apt, 6apu, 6apv, 6aqo, 6ar9, 7sb7, 8ts4 - TbHGPRT + inhibitor
    
• Hypoxanthine-guanine phosphoribosyltransferase ternary complex
  • 1bzy - hHPRT + inhibitor + guanine derivative
    
  • 1a95 - EcHPRT + guanine + PRPP derivative
    
  • 1a96 - EcHPRT + xanthine + PRPP derivative
    
  • 1i0i, 1i0l, 1i13, 1i14, 1tc2 – TcHPRT + pyrimidine derivative + PRPP derivative
    
  • 1p18 - TcHPRT (mutant) + pyrimidine derivative + PRPP
    
  • 1qk5 - TgHPRT (mutant) + XMP + pyrophosphate
    
  • 1fsg - TgHPRT + guanine derivative + PRPP
    
  • 1cjb - PfHPRT + pyrophosphate + inhibitor
    
  • 5knp, 5knq - MtHGPRT + pyrophosphate + nucleoside phosphonate
    
  • 4rhy - MtHGPRT + pyrophosphate + GMP
    
  • 6d9r - BaHGPRT + PRPP + deazaquanine
    
• Hypoxanthine-guanine-xanthine PRT or purine PRT
  • 5bqo - SsHGXPRT
    
  • 5bqp - SsHGXPRT + pyrophosphate
    
  • 7kl6, 7kl7 - HpHGXPRT
    
  • 7tux - PfHGXPRT + inhibitor
    
  • 7scr - TbHGXPRT + inhibitor
    
  • 8fwy - TcHGXPRT + xanthine + Pi
    
  • 8fwz, 8fx0, 8fx1, 8fx2, 8fx3 - TcHGXPRT + inhibitor
    
• Quinolinic acid phosphoribosyltransferase
  • 2jbm, 4kwv, 5ayx – hQAPRT
    
  • 3c2e - yQAPRT
    
  • 1o4u - TmQAPRT – Thermotoga maritima
    
  • 1qpo – MtQAPRT
    
  • 5hul - SpQAPRT (mutant)
    
  • 3paj - VcQAPRT (mutant)
    
• Quinolinic acid phosphoribosyltransferase complex
  • 5ayy - hQAPRT + quinolinic acid
    
  • 4kww – hQAPRT + phthalate
    
  • 5ayz – hQAPRT + nicotinate mononucleotide
    
  • 4i9a – QAPRT + nicotinate mononucleotide – pig
    
  • 3c2o - yQAPRT + quinolinic acid
    
  • 3c2f - yQAPRT + PRPP
    
  • 3c2r - yQAPRT + inhibitor
    
  • 3c2v - yQAPRT + inhibitor + PRPP
    
  • 1qap - StQAPRT + quinolinic acid
    
  • 1qpr - MtQAPRT + PRPP derivative
    
  • 1qpn – MtQAPRT + nicotinate mononucleotide
    
  • 1qpq - MtQAPRT + quinolinic acid
    
  • 2b7n – HpQAPRT + quinolinic acid
    
  • 2b7p – HpQAPRT + phthalate
    
  • 2b7q – HpQAPRT + nicotinate mononucleotide
    
  • 3gnn – BpQAPRT + peptide – Burkholderia pseudomallei
    
• Uracil phosphoribosyltransferase
  • 1w30, 5e38 - MtUPRT
    
  • 1bd3 - TgUPRT (mutant)
    
  • 1v9s - TtUPRT
    
  • 2e55 - UPRT – Aquifex aeolicus
    
  • 6wn8 - UPRT – Klebsiella pneumoniae
    
  • 2ehj - EcUPRT
    
  • 3dmp - BpUPRT
• Uracil phosphoribosyltransferase complex
  • 1upu - TgUPRT (mutant) + UMP
    
  • 1jlr - TgUPRT (mutant) + GTP
    
  • 1bd4 - TgUPRT (mutant) + uracil
    
  • 1upf - TgUPRT (mutant) + fluorouracil
    
  • 1jls - TgUPRT (mutant) + uracil + PRPP
    
  • 1i5e, 2igb - UPRT + UMP – Bacillus caldolyticus
    
  • 1o5o - TmUPRT + UMP
    
  • 1xtt, 1xtv - SsUPRT + UMP
    
  • 1xtu - SsUPRT + UMP + CTP
    
  • 1vst, 3g6w - SsUPRT + GTP + PRPP
    
  • 7rh8 - UPRT + UTP – Candida albicans
    
• Adenine phosphoribosyltransferase
  • 6hgp – hAPRT
    
  • 1g2p, 1g2q – yAPRT
    
  • 1qcc, 1qcd - LdAPRT
    
  • 2dy0 - EcAPRT
    
  • 4lza – APRT – Thermoanaerobacter pseudethanolicus
    
  • 4m0k – APRT – Rhodothermus marinus
    
  • 4mb6, 5y4a – YpAPRT – Yersinia pseudotuberculosis
    
  • 4trb – SsAPRT
    
  • 5yw2 - FtAPRT
    
  • 5zgo, 6fsp - TtAPRT
    
• Adenine phosphoribosyltransferase complex
  • 7y94 - hAPRT + adenine
    
  • 1ore, 1zn8, 1zn9, 6fcl - hAPRT + AMP
    
  • 4x44, 4x45 - hAPRT (mutant) + AMP
    
  • 6hgr - hAPRT + IMP
    
  • 6hgs - hAPRT + GMP
    
  • 6fch - hHGPRT + PRPP
    
  • 1zn7, 6fci - hHGPRT + adenine + PRPP
    
  • 6hgq - hHGPRT + hypoxanthine + PRPP
    
  • 6fd4, 6fd5, 6fd6 - hHGPRT (mutant) + adenine + PRPP
    
  • 5vjn, 5vjp – yAPRT1 + adenine + DIAB
    
  • 5yw5 - FtAPRT + adenine
    
  • 1qb7 - LdAPRT + adenine
    
  • 1qb8 - LdAPRT + AMP
    
  • 4trc - SsAPRT + adenine
    
  • 4ts5 - SsAPRT + AMP
    
  • 5b6h - YpAPRT + AMP
    
  • 5zc7, 5zmi, 5znq, 5zoc - YpAPRT + adenine
    
  • 5y07 - YpHGPRT + PRPP
    
  • 1mzv - LtAPRT + AMP
    
  • 4ts7 - SsAPRT + ADP
    
  • 1l1q - GiAPRT + adenine derivative
    
  • 1l1r - GiAPRT + adenine derivative + PRPP
    
  • 7xi2 - EcAPRT + Pi
    
  • 8izj - EcAPRT + AMP
    
  • 9vlf - APRT + AMP – Fusobacterium nucleatum
    
• Nicotinate mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase
  • 1l4b – StNN:DBI PRT
    
  • 4kqh - StNN:DBI PRT (mutant)
    
  • 1wx1 – TtNN:DBI PRT
    
  • 3u4g – PhNN:DBI PRT
    
  • 6b5f – NN:DBI – Yersinia enterocolitica
    
• Nicotinate mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase complex
  • 1jh8, 4kqf – StNN:DBI PRT + adenine
    
  • 1l4e, 1l4f, 1l4g, 1l4h, 1l4k, 1l4l, 1l4m, 1l4n, 1l5f, 1l5k, 1l5l, 1l5m, 1l5n, 1l5o - StNN:DBI PRT + product-aldimine complex
    
  • 1jha – StNN:DBI PRT + AMP + nicotinate
    
  • 1dov, 4kqi - StNN:DBI PRT (mutant) + nicotinate + α-ribazole phosphate
    
  • 1jhm – StNN:DBI PRT + benzimidazole
    
  • 1jho – StNN:DBI PRT + NaMN + benzimidazole
    
  • 1d0s, 1jhp – StNN:DBI PRT + benzimidazole derivative
    
  • 1jhq - StNN:DBI PRT + NaMN + benzimidazole derivative
    
  • 1jhr - StNN:DBI PRT + NaMN + hydroxypurine
    
  • 1jhu - StNN:DBI PRT + cresol
    
  • 4kqk - StNN:DBI PRT (mutant) + cresol
    
  • 1jhv - StNN:DBI PRT + nicotinate + cresol
    
  • 1d0v - StNN:DBI PRT + nicotinate + ribazole phosphate
    
  • 1jhx - StNN:DBI PRT + phenol
    
  • 1jhy - StNN:DBI PRT + phenol + nicotinate
    
  • 4kqj - StNN:DBI PRT (mutant) + NaMN + cresol
    
  • 4kqg - StNN:DBI PRT (mutant) + cobamide
    
• Anthranilate phosphoribosyltransferase
  • 7dsm – yANPRT
    
  • 7dsp – yANPRT (mutant)
    
  • 1o17 - SsANPRT
    
  • 1khd – PcANPRT – Pectobacterium carotovorum
    
  • 1v8g, 2elc - TtANPRT
    
  • 1vqu - ANPRT – Nostoc
    
  • 3qr9, 5c2l – MtANPRT
    
  • 4x5a - MtANPRT (mutant)
    
  • 4hkm - XcANPRT – Xanthomonas campestris
    
  • 4gtn – AcANPRT – Acinetobacter
    
  • 5noe, 5nof – ANPRT – Thermococcus kodkarensis
    
  • 8bfr – EcANPRT
    
  • 9ucw - ANPRT – Methanocaldcoccus jannaschii
    
• Anthranilate phosphoribosyltransferase complex containing anthranilate
  • 7dso, 7dsr - yANPRT + anthranilate derivative
    
  • 4n5v, 4n93, 4owm, 4own, 4owo, 4owq, 4ows, 4owu - MtANPRT + PRPP + anthranilate derivative
    
  • 4ij1, 4m0r, 4owv, 4n8q - MtANPRT + anthranilate derivative
    
  • 4x5d - MtANPRT (mutant) + anthranilate
    
  • 4x5e - MtANPRT (mutant) + anthranilate + POP
    
  • 1zyk - SsANPRT + anthranilate + PRPP
    
  • 4giu, 4gkm- PfANPRT + anthranilate derivative + PRPP
    
  • 4yi7 - AcMtANPRT + anthranilate
    
• Anthranilate phosphoribosyltransferase other complexes
  • 7dsj - yANPRT + PRPP
    
  • 1kgz - PcANPRT + PRPP
    
  • 1zvw, 5byt, 5c1r, 5c7s - MtANPRT + PRPP
    
  • 4x58, 4x59, 4x5b - MtANPRT (mutant) + PRPP
    
  • 4ztv, 5bne, 5bo2, 5bo3 - MtANPRT + inhibitor
    
  • 3qqs, 3qs8, 3qsa, 3r6c, 3r88, 3twp, 3uu1, 4zof, 4zoj, 4zok - MtANPRT + inhibitor + PRPP
    
  • 4x5c - MtANPRT (mutant) + PRPP + POP
    
  • 1zxy - SsANPRT + PRPP
    
  • 3gbr - SsANPRT (mutant) + PRPP
    
  • 1gxb - SsANPRT + POP
    
  • 2gvq - SsANPRT + anthranilate
    
  • 8bft - EcANPRT + OBGe peptide
    
• ATP phosphoribosyltransferase See ATP Phosphoribosyl Transferase
• Nicotinate phosphoribosyltransferase
  • 4yub - hNIPRT
    
  • 1vlp - yNIPRT
    
  • 1ybe - NIPRT – Agrobacterium tumefaciens
    
  • 1yir - NIPRT – Pseudomonas aeruginosa
    
  • 1ytd, 2i1o - TaNIPRT – Thermoplasma acidophilum
    
  • 2bpq - MtNIPRT
    
  • 2im5 - NIPRT – Porphyromonas gingivalis
    
  • 3os4 - NIPRT – Yersinia pestis
    
  • 4hl7 - VcNIPRT
    
• Nicotinate phosphoribosyltransferase complex
  • 1yte - TaNIPRT + PRPP
    
  • 1ytk - TaNIPRT + NAMN
    
  • 4mzy – NIPRT + malonate + Pi – Enterococcus faecalis
    
• Nicotinamide phosphoribosyltransferase
  • 2e5b – hNMPRT
    
  • 2gvl - mNMPRT – mouse
    
  • 2h3b – mNMPRT (mutant)
    
  • 2g95 - NMPRT - rat
    
  • 7yqo, 7yqp – XcNMPRT
    
• Nicotinamide phosphoribosyltransferase complex
  • 2gvg - hNMPRT + NMN
    
  • 2gvj - hNMPRT + FK-866
    
  • 2e5c - hNMPRT + PRPP
    
  • 2e5d, 8dsi - hNMPRT + nicotinamide
    
  • 3dgr - hNMPRT + ADP analog
    
  • 9iwt - hNMPRT + AMP
    
  • 4jnm, 4jr5, 4kfn, 4kfo, 4kfp, 4l4l, 4l4m, 4lts, 4lv9, 4lva, 4lvb, 4lvd, 4lvf, 4lvg, 4lww, 4m6p, 4m6q, 4n9b, 4n9c, 4n9d, 4n9e, 4o0z, 4o10, 4o12, 4o13, 4o14, 4o15, 4o16, 4o17, 4o18, 4o19, 4o1a, 4o1b, 4o1c, 4o1d, 4o28, 4wq6, 5kit, 5u2m, 5u2n, 5upe, 5upf, 5wi0, 5wi1, 6atb, 6azj, 6b75, 6b76, 6e68, 6peb, 6tac, 7ppe, 7ppf, 7ppg, 7pph, 7ppi, 8dsm, 8ivu - hNMPRT + inhibitor
    
  • 7enq, 8dtj - hNMPRT + activator
    
  • 8y55 - hNMPRT + drug
    
  • 8dsc, 8dsd, 8dse, 8f7l, 8tm7 - hNMPRT + nicotinamide + activator
    
  • 8dsh - hNMPRT + AMPcP + activator
    
  • 3dhd, 3dhf - hNMPRT + pyrophosphate + NMN
    
  • 3dkj, 3dkl - hNMPRT + benzamide + PRPP
    
  • 6ta0 - hNMPRT + nicotinic acid + PRPP
    
  • 6ta2 - hNMPRT + nicotinic acid + phosphate
    
  • 5lx3, 5lx5, 5nsd - hNMPRT + piperidine derivative
    
  • 2h3d - mNMPRT + NMN
    
  • 7q8t - mNMPRT + inhibitor
    
  • 2g96 - rNMPRT + NMN
    
  • 2g97, 3g8e - rNMPRT + FK-866
    
  • 7yqq - XcNMPRT + NMN
    
  • 7yqr - XcNMPRT + nicotinamide
    
  • 9ke8 - HdNMPRT + NMN – Haemophilus ducreyi
    
  • 9keo - HdNMPRT + nicotinamide
    
  • 9w5w - BphNMPRT + NAD – Bacillus phage
    
  • 9w5x - BphNMPRT + nicotinamide
    
• Decaprenyl-phosphate phosphoribosyltransferase
  • 8j8j – MtDPPRT + donor – Cryo EM
    
  • 8j8k – MtDPPRT + decaprenyl phosphate – Cryo EM
    

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