Pyruvate kinase 3D structures
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3D structures of pyruvate kinase
Updated on 14-September-2026
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- Pyruvate kinase muscle
- 1t5a, 1zjh, 3bjf, 3bjt, 9hib - hPyK M2 muscle - human
- 3g2g, 4qg6, 4qg8, 4qg9, 4qgc, 4wj8, 4yj5, 6b6u, 8hgf - hPyK M2 muscle (mutant)
- 3srf, 3srh – hPyK M1 muscle
- 6wp3, 6wp4, 6wp5, 6wp6 – hPyK M2 muscle (mutant)
- 1pkm, 1pyk – PyK muscle – cat
- 1f3w, 8f5t – rPyK muscle – rabbit
- 1f3x, 7r6y - rPyK muscle (mutant)
- Pyruvate kinase muscle binary complexes
- 4b2d, 9hic - hPyK M2 muscle + fructose bisphosphate
- 4rpp - hPyK M2 muscle (mutant) + fructose bisphosphate
- 4fxj - hPyK M2 muscle + phenylalanine
- 6gg3 - hPyK M2 muscle + alanine
- 6gg4 - hPyK M2 muscle + phenylalanine
- 6gg5 - hPyK M2 muscle + tryptophan
- 6gg6 - hPyK M2 muscle + serine
- 6nub - hPyK M2 muscle (mutant) + serine
- 6nu1 - hPyK M2 muscle + cysteine
- 6nu5 - hPyK M2 muscle (mutant) + cysteine
- 6ttf, 6tti, 6ttq - hPyK M2 muscle + inhibitor – Cryo EM
- 6tth - hPyK M2 muscle + threonine – Cryo EM
- 6v74, 6v75 - hPyK M2 muscle + asparagine
- 6v76 - hPyK M2 muscle + valine
- 8g2e, 9iqq, 9o3b - hPyK M2 muscle + activator
- 8f5u - rPyK muscle + pyruvate
- Pyruvate kinase muscle higher complexes
- 3me3 – hPyK M1/M2 muscle + aniline derivative + fructose bisphosphate
- 4g1n - hPyK M1/M2 muscle + pyridazine derivative + oxalate
- 3h6o - hPyK M1/M2 muscle + pyridazine derivative + fructose bisphosphate
- 3gqy, 3gr4, 3u2z - hPyK M1/M2 muscle + piperazine derivative + fructose bisphosphate
- 8hmq, 8hmr, 8hms, 8hmu - hPyK muscle (mutant) + Pi + fructose bisphosphate
- 5x0i - hPyK M2 muscle (mutant) + serine + fructose bisphosphate
- 7l21 - hPyK M2 muscle (mutant) + oxalate + fructose bisphosphate
- 6jfb - hPyK M2 muscle + serine + phosphate
- 5x1v, 5x1w - hPyK M2 muscle + activator + fructose bisphosphate
- 4jpg - hPyK M1/M2 muscle + pyrimidine derivative +fructosebisphosphate
- 3srd - hPyK M1/M2 muscle + oxalate + fructose bisphosphate
- 4fxf - hPyK M1/M2 muscle + oxalate + ATP + fructose bisphosphate
- 3n25 – rPyK M1/M2 muscle + proline + Mn + pyruvate
- 2g50 - rPyK M1/M2 muscle + alanine + Mn + pyruvate
- 8f6m - rPyK muscle + Ala + Mn + ADP
- 1pkn - rPyK muscle + Mn + pyruvate
- 1aqf – rPyK muscle + Mg + phospholactate
- 1a49, 1a5u - rPyK muscle + ATP + oxalate
- Pyruvate kinase liver
- 9vxp - hPyK liver – Cryo EM
- 2vgb – hPyK liver
- 2vgf, 2vgg, 2vgi 6nn5, 6nn7, 6nn8, 7qdn – hPyK liver (mutant)
- 9w4q, 9w7y, 9w81 - hPyK liver + activator – Cryo EM
- 8tbs, 8tbt, 8tbu - hPyK liver + activator
- 7fs7 - hPyK liver + modulator
- 9wdo, 9wdq, 9wdr, 9edt - hPyK liver + drug – Cryo EM
- 8xfd - hPyK liver + activator
- 9r3h, 9r3i, 9r3l, 9r3m, 9r3o, 9rdf, 9rfq, 9rft - hPyK liver + fluorescent probe
- 9wez - hPyK liver + fructose bisphosphate – Cryo EM
- 6nn4 - hPyK M2 liver (mutant) + fructose bisphosphate
- 6ech, 6eck - PyK liver + fructose bisphosphate - rat
- 5sc8, 5sc9, 5sca, 5scb, 5scc, 5scd, 5sce, 5scf, 5scg, 5sch, 5sci, 5scj, 5sck, 5scl, 5sdt, 7qzu - hPyK liver + anthracene derivative + fructose bisphosphate
- 7frv, 7frw, 7frx, 7fry, 7frz, 7fs0, 7fs1, 7fs2, 7fs3, 7fs4, 7fs5, 7fs6, 7fs8, 7fs9, 7fsa, 7fsb, 7fsc, 7fsd - hPyK liver + modulator + fructose bisphosphate
- 4ima, 4ip7 - hPyK liver (mutant) + citrate + adenosine + fructose bisphosphate
- Pyruvate kinase
- 6du6 – PyK - mosquito
- 1pky, 4yng, 6k0k – EcPyK - Eschericia coli
- 1e0t, 1e0u, 8edq, 8edr, 8eds, 8edt, 8eq0, 8eq1, 8eq3, 8eu4 - EcPyK (mutant)
- 3t05, 3t0t – SaPyK – Staphylococcus aureus
- 3qtg – PyK – Pyrobaculum aerophilum
- 4krz – TcPyK – Trypanosoma cruzei
- 5wrp - MtPyK – Mycobacterium tuberculosis
- 1pkl, 3e0w, 3hqn – LmPyK – Leishmania mexicana
- 3khd, 7z4m – PfPyK – Plasmodium falciparum
- 7z4q, 7z4r - PfPyK (mutant)
- 3eoe, 3gg8 – PyK – Toxoplasma gondii
- 3ma8, 4drs – CpPyK – Cryptosporidium parvum
- 2e28 - PyK (mutant) – Geobacillus stearothermophilus
- 7oo1 – PaPyK – Pseudomonas aeruginosa
- 7ueh – PyK – Zymomonas mobilis
- 8ias - SpPyK – Streptococcus pneumoniae
- 8iw2 - PyK – Entamoeba histolytica
- Pyruvate kinase binary complex
- 8x4r – hPyK + Phe
- 3qv9 – TcPyK + Ponceau S
- 3qv6 – LmPyK + acid blue 80
- 3e0v – LmPyK + sulfate
- 3hqq - LmPyK + fructose bisphosphate
- 3qv8 – LmPyK + benzothiazole
- 3pp7 – LmPyK + suramin
- 3is4, 3ktx – LmPyK + pyrenetetrasulfonic acid
- 3t07 – SaPyK + bis-indole alkaloid
- 4hyw – TbPyK + fructose bisphosphate – Trypanosoma brucei
- 6su1, 6su2 – PyK + citrate – Trypanosoma congolense
- 5ws8 - MtPyK + oxalate
- 6p0y - CpPyK + ADP
- 8iav - SpPyK + fructose bisphosphate
- 8iat - SpPyK + oxalate
- 8iaw - SpPyK + phosphoenolpyruvate
- 7z4n -PfPyK + pyruvate
- 8rtf, 8rvr -PyK + antibody – Trypanosoma congolense
- Pyruvate kinase higher complexes
- 8xfd – hPyK + activator + fructose bisphosphate
- 1a3w – yPyK + Mn + phosphoglycolic acid + fructose bisphosphate – yeast
- 1a3x - yPyK + Mn + phosphoglycolic acid
- 4hyv – TbPyK + phosphoenolpyruvate + fructose bisphosphate
- 4kct – TbPyK + pyruvate + fructose bisphosphate
- 4kcu – TbPyK + malate + fructose bisphosphate
- 4kcv – TbPyK + oxoglutarate + fructose bisphosphate
- 4kcw – TbPyK + oxalate + fructose bisphosphate
- 4ks0 – TcPyK + oxalate + fructose bisphosphate
- 5ws9 – MtPyK + oxalate + AMP + ATP
- 5wsa – MtPyK + oxalate + glucose-6-phosphate
- 5wsb, 5wsc – MtPyK + oxalate + glucose-6-phosphate + AMP
- 6ito – MtPyK + oxalate + ribose-5-phosphate + AMP
- 3hqo – LmPyK + ATP + oxalate
- 3hqp - LmPyK + ATP + oxalate + fructose bisphosphate
- 3qv7 – LmPyK + acid blue 25 + Ponceau S
- 3srk – LmPyK + saccharine + inhibitor
- 6qxl – PaPyK + malonate + glucose-6-phosphate + Mg
- 6ksh – PfPyK + oxalate + ATP
- 8iax - SpPyK + fructose bisphosphate + phosphoenolpyruvate
- 8iau - SpPyK + fructose bisphosphate + oxalate
- 8xw6, 8xw7, 8xw8, 8xw9, 8zly - SpPyK + fructose bisphosphate + oxalate + nucleotide
