5dws | pdb_00005dws

Crystal Structure of ITCH WW3 domain in complex with TXNIP peptide

spinqualitylabelsall models 5dws, resolution 1.65Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5dws is a 8 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 4rre. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.65Å Ligands: ACE, NH2, UNX Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function TXNIP_HUMAN May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). See Also Ubiquitin protein ligase 3D structures

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