Fibroblast growth factor receptor

spinqualitylabelsall models Human fibroblast growth factor receptor 1 ligand-binding domain modules D2 and D3 (pink and yellow) complex with fibroblast growth factor 1 (cyan and green) and sulfate (PDB code 1evt) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Fibroblast growth factor receptors (FGFR) are receptors which bind fibroblast growth factors (FGF). Each FGFR can activate several FGFs. Five FGFRs have been identified so far. FGFRs differ in their ligand specificity and tissue distribution. The binding of FGF to FGFR starts a cascade of signaling which influences mitogenesis and differentiation. See also Receptor tyrosine kinases and Kinase-linked, enzyme-linked and related receptors. FGFR2 is essential for limb induction. FGFR3 is involved in skeletal dysplasia. Disease Mutation in FGFR3 causes achondroplasia and is involved in myeloma. Mutations in FGFR2 cause Crouzon syndrome. Structural insights FGFR consist of an extracellular ligand-binding domain (LBD), transmembrane helix domain and cytoplasmic tyrosine kinase activity domain (TKD) with phosphorylated tyrosine designated PTR. FGFR LBD contains 3 immunoglobulin-like domains D1, D2 and D3. Human fibroblast growth factor receptor 1 ligand-binding domain modules D2 and D3 with 2 molecules of fibroblast growth factor 1 (PDB code 1evt). 3D structures of fibroblast growth factor receptor Fibroblast growth factor receptor 3D receptor

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