Galactose oxidase

spinqualitylabelsall models Galactose oxidase with Cu+2 (orange) and Na+ ions (purple), 1gog Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Galactose oxidase (GAO) catalyzes the oxidation of D-galactose using O2 to D-galacto-hexodialdose and hydrogen peroxide. GAO catalytic motif is a free radical-coupled copper. Structural highlights GAO uses copper and active site post-translational cross-linking of Cys228 and Tyr272 via a thioester bond for activity. Water molecules shown as red spheres. Na coordination site. See also: Thioester protein crosslinks Thioether protein crosslinks.

3D structures of galactose oxidase

Updated on 06-July-2026

Thioester protein crosslinks, Thioether protein crosslinks, 1goh – GAO + Cu – Hypomyces rosellus
1k3i – FuGAO precursor – Fusarium
8tx5, 8tx6 - FuGAO + Cu 1t2x – FuGAO (mutant) + Cu
2vz3 - GzGAO + Cu – Gibberella zeae
2eib, 2eic, 2eid, 2wq8 - GzGAO (mutant) + Cu
6xlt – GzGAO + Cu
6xlr, 6xls – GzGAO + Cu + modified Tyr272
2eie – GzGAO + N3
2jkx – GzGAO
2vz1 – GzGAO premature

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Michal Harel, Alexander Berchansky