Thrombospondin

spinqualitylabelsall models Human TSP-1 Nterminal complex with Arixtra heparin (PDB code 1za4) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Thrombospondin (TSP) are glycoproteins released in response to thrombin stimulation. TSP is a transient component of extracellular matrix in developing tissues. Relevance TSP-1 and TSP-2 are potent inhibitors of angiogenesis and thus are studied in cancer treatments. Disease TSP-2 mutation is associated with coronary artery disease. Structural highlights The N-terminal of TSP-1 mediates its interaction with integrins during cell adhesion, with lipoproteinreceptor-related protein during uptake and clearance and with fibrinogen during platelet aggregation. The arginine and lysine side chains of the N-terminal interact with the heparin sulfate groups.

3D structures of thrombospondin

Updated on 19-August-2024

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• Thrombospondin-1
  • 1ux6 – hTSP-1 C-terminal (mutant) 831-1170 + Ca - human
    
  • 1lsl, 3r6b – hTSP-1 repeats 2-3 434-547
    
  • 1z78, 2erf, 2es3, 2ouh, 2ouj – hTSP-1 N-terminal 25-233
    
  • 7yyk – hTSP-1 378-547
    
  • 1za4 – hTSP-1 N-terminal + heparin
    
• Thrombospondin-2
  • 1yo8 – hTSP-2 C-terminal
    
  • 2rhp – hTSP-2 signature domain (mutant)
    

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