2g70 | pdb_00002g70

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File:2g70.png

Template:STRUCTURE 2g70

Structure of human PNMT in complex with inhibitor 3-hydroxymethyl-7-nitro-THIQ and AdoMet (SAM)

Template:ABSTRACT PUBMED 17845018

About this Structure

2g70 is a 2 chain structure of Phenylethanolamine N-methyltransferase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Gee CL, Drinkwater N, Tyndall JD, Grunewald GL, Wu Q, McLeish MJ, Martin JL. Enzyme adaptation to inhibitor binding: a cryptic binding site in phenylethanolamine N-methyltransferase. J Med Chem. 2007 Oct 4;50(20):4845-53. Epub 2007 Sep 11. PMID:17845018 doi:10.1021/jm0703385
  2. Lu J, Edwards RA, Wong JJ, Manchak J, Scott PG, Frost LS, Glover JN. Protonation-mediated structural flexibility in the F conjugation regulatory protein, TraM. EMBO J. 2006 Jun 21;25(12):2930-9. Epub 2006 May 18. PMID:16710295

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