3bxq | pdb_00003bxq

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Template:STRUCTURE 3bxq

File:3bxq.png

The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition

Template:ABSTRACT PUBMED 18332129

About this Structure

3bxq is a 4 chain structure of Molecular Playground/Insulin. Full crystallographic information is available from OCA.

See Also

Reference

  1. Hua QX, Nakagawa SH, Jia W, Huang K, Phillips NB, Hu SQ, Weiss MA. Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications. J Biol Chem. 2008 May 23;283(21):14703-16. Epub 2008 Mar 10. PMID:18332129 doi:10.1074/jbc.M800313200
  2. Wan ZL, Huang K, Hu SQ, Whittaker J, Weiss MA. The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition. J Biol Chem. 2008 Jul 25;283(30):21198-210. Epub 2008 May 20. PMID:18492668 doi:10.1074/jbc.M800235200

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