2r42 | pdb_00002r42

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Template:STRUCTURE 2r42

The Biochemical and Structural Basis for feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism

Template:ABSTRACT PUBMED 18302342

Disease

[KIME_RAT] Note=Mutation in the mevalonate kinase gene causes mevalonicaciduria.

Function

[KIME_RAT] May be a regulatory site in cholesterol biosynthetic pathway.

About this Structure

2r42 is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  1. Fu Z, Voynova NE, Herdendorf TJ, Miziorko HM, Kim JJ. Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism. Biochemistry. 2008 Mar 25;47(12):3715-24. Epub 2008 Feb 27. PMID:18302342 doi:10.1021/bi7024386

Proteopedia Page Contributors and Editors (what is this?)

OCA

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