3c6m | pdb_00003c6m
From Proteopedia
Crystal structure of human spermine synthase in complex with spermine and 5-methylthioadenosine
Disease
[SPSY_HUMAN] Defects in SMS are the cause of X-linked syndromic mental retardation Snyder-Robinson type (MRXSSR) [MIM:309583]. Characterized by moderate intellectual deficit, hypotonia, an unsteady gait, osteoporosis, kyphoscoliosis and facial asymmetry. Transmission is X-linked recessive.[1]
Function
[SPSY_HUMAN] Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM).
About this Structure
3c6m is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Wu H, Min J, Zeng H, McCloskey DE, Ikeguchi Y, Loppnau P, Michael AJ, Pegg AE, Plotnikov AN. Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism. J Biol Chem. 2008 Jun 6;283(23):16135-46. Epub 2008 Mar 26. PMID:18367445 doi:https://dx.doi.org/10.1074/jbc.M710323200
- ↑ Cason AL, Ikeguchi Y, Skinner C, Wood TC, Holden KR, Lubs HA, Martinez F, Simensen RJ, Stevenson RE, Pegg AE, Schwartz CE. X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome. Eur J Hum Genet. 2003 Dec;11(12):937-44. PMID:14508504 doi:10.1038/sj.ejhg.5201072
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Spermine synthase
- Arrowsmith, C H.
- Bochkarev, A.
- Edwards, A M.
- Loppnau, P.
- Min, J.
- Pegg, A E.
- Plotnikov, A N.
- SGC, Structural Genomics Consortium.
- Sundstrom, M.
- Weigelt, J.
- Wu, H.
- Zeng, H.
- Phosphoprotein
- Sgc
- Spermidine aminopropyltransferase
- Spmsy
- Structural genomic
- Structural genomics consortium
- Transferase
