3q90 | pdb_00003q90
From Proteopedia
Crystal structure of the NTF2 domain of Ras GTPase-activating protein-binding protein 1
Function
[G3BP1_HUMAN] May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.[1] [2]
About this Structure
3q90 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Costa M, Ochem A, Staub A, Falaschi A. Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway. Nucleic Acids Res. 1999 Feb 1;27(3):817-21. PMID:9889278
- ↑ Tourriere H, Gallouzi IE, Chebli K, Capony JP, Mouaikel J, van der Geer P, Tazi J. RasGAP-associated endoribonuclease G3Bp: selective RNA degradation and phosphorylation-dependent localization. Mol Cell Biol. 2001 Nov;21(22):7747-60. PMID:11604510 doi:10.1128/MCB.21.22.7747-7760.2001
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Arrowsmith, C H.
- Berg, S Van Der.
- Berglund, H.
- Bountra, C.
- Collins, R.
- Edwards, A M.
- Ekblad, T.
- Flodin, S.
- Flores, A.
- Graslund, S.
- Hammarstrom, M.
- Johansson, I.
- Karlberg, T.
- Kol, S.
- Kotenyova, T.
- Kouznetsova, E.
- Moche, M.
- Nordlund, P.
- Nyman, T.
- Persson, C.
- SGC, Structural Genomics Consortium.
- Schuler, H.
- Schutz, P.
- Siponen, M I.
- Thorsell, A G.
- Tresaugues, L.
- Wahlberg, E.
- Weigelt, J.
- Welin, M.
- Dna and rna binding
- Hydrolase
- Nucleus
- Plasma membrane
- Protein binding and helicase
- Sgc
- Structural genomic
- Structural genomics consortium
