3rbg | pdb_00003rbg
From Proteopedia
Crystal structure analysis of Class-I MHC restricted T-cell associated molecule
Function
[CRTAM_HUMAN] Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.[1] [UniProtKB:Q149L7]
About this Structure
3rbg is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Rubinstein R, Ramagopal UA, Nathenson SG, Almo SC, Fiser A. Functional classification of immune regulatory proteins. Structure. 2013 May 7;21(5):766-76. doi: 10.1016/j.str.2013.02.022. Epub 2013 Apr, 11. PMID:23583034 doi:10.1016/j.str.2013.02.022
- ↑ Boles KS, Barchet W, Diacovo T, Cella M, Colonna M. The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. Blood. 2005 Aug 1;106(3):779-86. Epub 2005 Apr 5. PMID:15811952 doi:10.1182/blood-2005-02-0817
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Almo, S C.
- Fiser, A.
- IFN, Atoms-to-Animals:.The Immune Function Network.
- NYSGRC, New York Structural Genomics Research Consortium.
- Nathenson, S G.
- Ramagopal, U A.
- Rubinstein, R.
- Toro, R.
- Atoms-to-animals: the immune function network
- Crtam
- Ifn
- Igv
- Immune system
- New york structural genomics research consortium
- Nysgrc
- Psi-biology
- Structural genomic
