Adapter molecule crk

<StructureSection load='1cka' size='350' side='right' caption='Structure of mouse Crk N terminal SH3 domain complex with proline-rich peptide (PDB entry 1cka)' scene=>

Adapter molecule crk (Crk) (CT10 Regulatior of Kinase) is a proto-oncogene which participates in the Reelin signaling cascade. Crk binds to several tyrosine-phosphorylated proteins. Crk domains include several SH2 and SH3 domains.

3D structures of adpter molecule crk

1m30, 1m3a, 1m3b, 1m3c – mCrk N terminal SH3 (mutant) – mouse - NMR
2ggr – mCrk C terminal SH3 - NMR
2l3p, 2l3q, 2l3s – Crk residues 220-297 – chicken – NMR
1cka, 1ckb – mCrk N terminal SH3 + proline-rich peptide
1b07 – mCrk N terminal SH3 + SH3 peptoid inhibitor
1ju5 – hCrk SH2 + phosphopeptide + Abl SH3 - human

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Michal Harel, Alexander Berchansky