1h1d | pdb_00001h1d
From Proteopedia
CATECHOL O-METHYLTRANSFERASE
Template:ABSTRACT PUBMED 12237326
Function
[COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
About this Structure
1h1d is a 1 chain structure with sequence from Buffalo rat. Full crystallographic information is available from OCA.
See Also
Reference
- Bonifacio MJ, Archer M, Rodrigues ML, Matias PM, Learmonth DA, Carrondo MA, Soares-Da-Silva P. Kinetics and crystal structure of catechol-o-methyltransferase complex with co-substrate and a novel inhibitor with potential therapeutic application. Mol Pharmacol. 2002 Oct;62(4):795-805. PMID:12237326
