4npl | pdb_00004npl
From Proteopedia
Crystal structure of Zebrafish ALKBH5 in complex with alpha-ketoglutarate
Template:ABSTRACT PUBMED 24561204
Function
[ALKB5_DANRE] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).
About this Structure
4npl is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Chen W, Zhang L, Zheng G, Fu Y, Ji Q, Liu F, Chen H, He C. Crystal structure of the RNA demethylase ALKBH5 from zebrafish. FEBS Lett. 2014 Mar 18;588(6):892-8. doi: 10.1016/j.febslet.2014.02.021. Epub, 2014 Feb 20. PMID:24561204 doi:https://dx.doi.org/10.1016/j.febslet.2014.02.021
