2e6d | pdb_00002e6d

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Template:STRUCTURE 2e6d

Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with fumarate

Template:ABSTRACT PUBMED 18808149

Function

[Q4D3W2_TRYCR] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.

About this Structure

2e6d is a 2 chain structure with sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.

See Also

Reference

  1. Inaoka DK, Sakamoto K, Shimizu H, Shiba T, Kurisu G, Nara T, Aoki T, Kita K, Harada S. Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction. Biochemistry. 2008 Oct 14;47(41):10881-91. Epub 2008 Sep 23. PMID:18808149 doi:10.1021/bi800413r

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