Sequestosome

spinqualitylabelsall models Structure of mouse sequestosome UBA domain (PDB code 3b0p) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Sequestosome (SQS) or p62, is required for the formation and autophagic degredation of polyubiquitin-containg bodies. SQS may regulate signaling cascades through ubiquitination. SQS is a multi-domain protein. SQS domain structure includes: PB1 domain which contains Phox and Berm1 ZZ-type zinc finger SMIR – SOD interaction domain TB – TRAF6 binding motif LC3 – microtubule-associated protein 1 light chain 3B LIR – interaction region UBA – ubiquitin association domain. 3D structures of sequestosome Updated on 08-June-2014 1q02, 2jy7, 2jy8, 2k0b, 2knv – SQS UBA domain – human - NMR 3b0p – mSQS UBA domain – mouse 2rru – mSQS UBA domain - NMR 2ktr – rSQS PB1 domain – rat - NMR 2kkc – rSQS PB1 domain (mutant) - NMR 3ade – mSQS + KEAP-1 – mouse

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Michal Harel