3vdd | pdb_00003vdd

Structure of HRV2 capsid complexed with antiviral compound BTA798

spinqualitylabelsall models 3vdd, resolution 3.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3vdd is a 4 chain structure with sequence from Hrv-2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: BT8 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Respiratory infections caused by human rhinovirus are responsible for severe exacerbations of underlying clinical conditions such as asthma in addition to their economic cost in terms of lost working days due to illness. While several antiviral compounds for treating rhinoviral infections have been discovered, none have succeeded, to date, in reaching approval for clinical use. We have developed a potent, orally available rhinovirus inhibitor 6 that has progressed through early clinical trials. The compound shows favorable pharmacokinetic and activity profiles and has a confirmed mechanism of action through crystallographic studies of a rhinovirus-compound complex. The compound has now progressed to phase IIb clinical studies of its effect on natural rhinovirus infection in humans. An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus.,Feil SC, Hamilton S, Krippner GY, Lin B, Luttick A, McConnell DB, Nearn R, Parker MW, Ryan J, Stanislawski PC, Tucker SP, Watson KG, Morton CJ ACS Med Chem Lett. 2012 Feb 13;3(4):303-7. doi: 10.1021/ml2002955. eCollection, 2012 Apr 12. PMID:24900468 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Human rhinovirus

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