2gx9 | pdb_00002gx9

X-ray strucutre of influenza virus NS1 effector domain

spinqualitylabelsall models 2gx9, resolution 2.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2gx9 is a 2 chain structure with sequence from Unidentified influenza virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SCN NonStd Res: MSE Gene: Segment 8 - NS1 (unidentified influenza virus) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The nonstructural protein NS1 of influenza virus is an antagonist of host immune responses and is implicated in virulence. It has two domains, an N-terminal double-stranded RNA-binding domain (RBD) and an effector domain crucial for RBD function, for nuclear export and for sequestering messenger RNA-processing proteins. Here we present the crystallographic structure of the effector domain, which has a novel fold and suggests mechanisms for increased virulence in H5N1 strains. X-ray structure of influenza virus NS1 effector domain.,Bornholdt ZA, Prasad BV Nat Struct Mol Biol. 2006 Jun;13(6):559-60. Epub 2006 May 21. PMID:16715094 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Nonstructural protein

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