1av2 | pdb_00001av2

Gramicidin A/CsCl complex, active as a dimer

spinqualitylabelsall models 1av2, resolution 1.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1av2 is a 4 chain structure with sequence from Brevibacillus brevis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL, CS, MOH NonStd Res: DLE, DVA, ETA, FVA Related: 1tk2, 2xdc, 1bdw, 1c4d, 1gmk, 1grm, 1jno, 1kqe, 1mag, 1mic, 1ng8, 1nrm, 1nru, 1nt5, 1jo3, 1jo4, 1nt6, 1tkq, 1w5u, 2izq, 3l8l, 1al4, 1alx, 1alz Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The linear pentadecapeptide antibiotic, gramicidin D, is a naturally occurring product of Bacillus brevis known to form ion channels in synthetic and natural membranes. The x-ray crystal structures of the right-handed double-stranded double-helical dimers (DSDH) reported here agree with 15N-NMR and CD data on the functional gramicidin D channel in lipid bilayers. These structures demonstrate single-file ion transfer through the channels. The results also indicate that previous crystal structure reports of a left-handed double-stranded double-helical dimer in complex with Cs+ and K+ salts may be in error and that our evidence points to the DSDH as the major conformer responsible for ion transport in membranes. The conducting form of gramicidin A is a right-handed double-stranded double helix.,Burkhart BM, Li N, Langs DA, Pangborn WA, Duax WL Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):12950-5. PMID:9789021 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Gramicidin

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