Dehalogenase

<StructureSection load='2edc' size='340' side='right' caption='Structure of haloalkane dehalogenase complex with I- ion (purple) (PDB code 2edc).' scene=>

Function

Dehalogenases catalyze the removal of halogen atom from substrates.
• Haloalkane dehalogenase converts haloalkanes to alcohol
• Halohydrin dehalogenase converts halohydrins to epoxide
• L-2 haloacid dehalogenase converts haloacids to hydroxyacid
• 4-chlorobenzoyl CoA dehalogenase converts 4-chlorobenzoyl CoA to 4-hydroxybenzoyl CoA
• Fluoroacetate dehalogenase converts fluoroacetate to glycolate
• Iodotyrosine dehalogenase converts iodotyrosine to tyrosine
• cis- and trans-3-chloroacrylic acid dehalogenase converts 3-chloroacrylate to malonate semialdehyde
• 5-chloromuconolactone dehalogenase converts 5-chloromuconolactone to E-dienelactone.

3D structures of dehalogenase

Updated on 23-November-2014

{"openlevels":0}

• Haloalkane dehalogenase (HDH)
  • 2had, 1ede, 2pky, 2yxp – XaHDH – Xanthobacter autotrophicus
    
  • 1hde, 1be0, 1bee, 1bez – XaHDH (mutant)
    
  • 1bn6, 1bn7, 4kaa, 4kac, 4kaf – RrHDH – Rhodococcus rhodochrous
    
  • 2v9z – RrHDH (mutant)
    
  • 1cv2 – SpHDH – Sphingomonas paucimobilis
    
  • 4h77 – SphHDH – Sphignobium
    
  • 4h7d – SphHDH (mutant)
    
• Haloalkane dehalogenase complex with halide ion
  • 1edb, 1edd, 2eda, 2edc, 2dhe, 1b6g – XaHDH + halide
    
  • 1cij – XaHDH (mutant) + halide
    
  • 1d07, 1iz7, 1k5p, 1mj5 – SpHDH + halide
    
  • 3fbw, 1cqw, 4hzg – RrHDH + halide
    
  • 3a2m, 3a2n, 3afi – BjHDH + halide – Bradyrhizobium japonicum
    
  • 3a2l – BjHDH (mutant) + halide
    
  • 4k2a – HDH + halide – Bradyrhizobium elkanii
    
  • 3rk4, 3sk0, 4f5z, 4f60 – RrHDH (mutant) + halide
    
  • 4h7e, 4h7f, 4h7h, 4h7i, 4h7j 4h7k – SphHDH (mutant) + halide
    
  • 4brz – RhHDH + halide - Rhodobacteraceae
    
• Haloalkane dehalogenase other complexes
  • 2dhc – XaHDH + ethylene dichloride
    
  • 2dhd – XaHDH + amono-chloroethoxy-oxobutanoic acid + Cl
    
  • 1g42 – SpHDH + dichloropropane + Cl
    
  • 2bfn – SpHDH + dichloropropanol + Cl
    
  • 1g4h – SpHDH (mutant) + butanol + Cl
    
  • 1g5f – SpHDH + dichloroethane + Cl
    
  • 1iz8 – SpHDH + propanediol + Cl
    
  • 4c6h – RhHDH + hexanol + Cl
    
  • 3fwh, 3g9x, 4e46 – RrHDH + isopropanol + Cl
    
  • 1k6e – SpHDH + bromopropanol + Cl + Br
    
  • 1k63 – SpHDH + bromopropene-1-ol + Cl + Br
    
  • 4fwb – SpHDH (mutant) + trichloropropane + Cl
    
• Fluoroacetate dehalogenase (FDH)
  • 1y37 – BuFDH – Burkholderia
    
  • 3r3u – RpFDH – Rhodopseudomonas palustris
    
  • 3r40, 3r41 – RpFDH (mutant)
    
• Fluoroacetate dehalogenase complexes
  • 3r3v, 3r3y – RpFDH (mutant) + fluoroacetate
    
  • 3r3w – RpFDH (mutant) + chloroacetate
    
  • 3r3x – RpFDH (mutant) + bromoacetate
    
  • 3r3z – RpFDH + glycolate
    
  • 3b12 – BuFDH (mutant) + fluoroacetate
    
• Halohydrin dehalogenase (HHDH)
  • 1zmo – HHDH – Anthrobacter
    
  • 3zn2 – AtHHDH – Agrobacterium tumefaciens
    
• Halohydrin dehalogenase complexes
  • 1pwx – AtHHDH + Br
    
  • 1px0 – AtHHDH + haloalcohol mimic
    
  • 1zo8 – AtHHDH + p-nitrostyrene oxide
    
  • 4ixt – AtHHDH (mutant) + ethyl cyano-hydroxybutyrate
    
  • 4ixw – RrHHDH (mutant) + ethyl oxiranyl acetate – Rhizobium radiobacter
    
  • 4iy1 – RrHHDH + Cl
    
• L-2-haloacid dehalogenase (LHDH)
  • 1jud – PsLHDH – Pseudomonas
    
  • 2w43 – StLHDH – Sulfolobus tokodaii
    
• L-2-haloacid dehalogenase complexes
  • 1aq6, 1qq5 – XaLHDH + formic acid
    
  • 1zrm – PsLHDH (mutant) + butanoic acid
    
  • 1zrn – PsLHDH (mutant) + acetic acid
    
  • 1qh9 – PsLHDH + lactic acid
    
  • 2w11 – StLHDH + lactic acid
    
  • 1qq6, 1qq7 – XaLHDH + aspartate carboxymethyl ester + Cl
    
• DL-2-haloacid dehalogenase (DLHDH)
  • 4n2x – MeDLHDH – Methylobacterium
    
  • 3wj8 – MeDLHDH + bromo-methylpropionate
    
• Iodotyrosine dehalogenase (ITDH)
  • 3gb5 – mITDH – mouse
    
  • 3to0 – mITDH (mutant)
    
  • 3gfd – mITDH + iodotyrosine
    
  • 3tnz – mITDH (mutant) + iodotyrosine
    
  • 3gh8 – mITDH + diiodotyrosine
    
• cis-3-chloroacrylic acid dehalogenase (CaaD)
  • 2flz, 3mf8 – CbCaaD – Coryneform bacterium
    
  • 3mf7 – CbCaaD + oxirane-carboxylate
    
  • 2flt – CbCaaD + lactic acid
    
• trans-3-chloroacrylic acid dehalogenase (TaaD)
  • 3ej3 – PpTaaD α+β subunits – Pseudomonas pavonacea
    
  • 3ej7, 3ej9 – PpTaaD α (mutant) +β subunits
    
  • 1s0y – PpTaaD α+β subunits + malonic acid
    
• 5-chloromuconolactone dehalogenase (ClcF)
  • 3znu, 3znj, 4fpi – RoClcF – Rhodococcus opacus
    
  • 3zo7 – RoClcF + 5-chloromuconolactone
    
• 4-chlorobenzoyl CoA dehalogenase (CBCD)
  • 1nzy – PsCBCD
    
  • 1jxz – PsCBCD + hydroxybenzoyl CoA
    

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Michal Harel, Alexander Berchansky, Joel L. Sussman