1tip | pdb_00001tip
THE BISPHOSPHATASE DOMAIN OF THE BIFUNCTIONAL RAT LIVER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE
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| 1tip, resolution 2.2Å | |||||||||||||
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| Ligands: | F6P | ||||||||||||
| Gene: | A CODING REGION WHICH COVERS (Rattus norvegicus) | ||||||||||||
| Activity: | Fructose-2,6-bisphosphate 2-phosphatase, with EC number 3.1.3.46 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Overview
The crystal structure of the fructose-2,6-bisphosphatase domain trapped during the reaction reveal a phosphorylated His 258, and a water molecule immobilized by the product, fructose-6-phosphate. The geometry suggests that the dephosphorylation step requires prior removal of the product for an 'associative in-line' phosphoryl transfer to the catalytic water.
About this Structure
1TIP is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Crystal structure of a trapped phosphoenzyme during a catalytic reaction., Lee YH, Olson TW, Ogata CM, Levitt DG, Banaszak LJ, Lange AJ, Nat Struct Biol. 1997 Aug;4(8):615-8. PMID:9253407
Page seeded by OCA on Thu Mar 20 14:18:53 2008
