Structural highlights
4lsg is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | HG |
| Related: | 4ksb, 4ksc, 3g5u |
| Gene: | Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3 (Mus musculus) |
| Activity: | Xenobiotic-transporting ATPase, with EC number 3.6.3.44 |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Function
[MDR1A_MOUSE] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.[1]
References
- ↑ Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science. 2009 Mar 27;323(5922):1718-22. PMID:19325113 doi:323/5922/1718
