4jyt | pdb_00004jyt

Crystal Structure of Matriptase in complex with Inhibitor

spinqualitylabelsall models 4jyt, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4jyt is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: N4A Related: 4jzi, 4jz1 Gene: ST14, PRSS14, SNC19, TADG15 (HUMAN) Activity: Matriptase, with EC number 3.4.21.109 Resources: FirstGlance, OCA, RCSB, PDBsum Disease [ST14_HUMAN] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:610765]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair. Function [ST14_HUMAN] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. See Also Matriptase

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