CD3

spinqualitylabelsall models Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry 1sy6) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function CD3 (or Cluster of Differentiation 3) is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single Immunorecetor Tyrosine-based Activation Motif (ITAM). Human CD3 extracellular domain with antibody light chain and heavy chain (PDB entry 1sy6). Relevance Drugs which bind to CD3 are tested as immunorepressants.

3D structures of CD3

Updated on 24-November-2015

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• CD3 ε chain
  • 1sy6 – hCD3 ITAM + Syk kinase – human
    
  • 2jxb – hCD3 domain SH3-1
    
  • 2k4f – mCD3 ITAM – mouse - NMR
    
  • 3r08 – mCD3 extracellular domain + antibody
    
  • 2mim – CD3 – chicken
    
• CD3 εγ dimer
  • 1jbj – hCD3 extracellular domain - NMR
    
  • 1sy6 – hCD3 extracellular domain + antibody
    
• CD3 εδ dimer
  • 1xiw – hCD3 extracellular domain + antibody
    
  • 1xmw – mCD3 extracellular domain ε/sCD3 extracellular domain δ – sheep
    
• CD3 ζ chain
  • 1ygr, 2oq1 – hCD3 ITAM + CD45 protein tyrosine phosphatase
    
  • 3ik5, 3ioz – hCD3 ITAM + NEF
    
  • 2hac – hCD3 transmembrane domain - NMR
    

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Michal Harel, Alexander Berchansky